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The Sarcoplasmic Reticulum Modulates Ca2+- Dependent Vasoconstriction

  • Regent Laporte
  • Ismail Laher
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)

Abstract

Calcium ions (Ca2+) play a central role in muscle contraction in that they regulate events that result in excitation-contraction coupling. Signaling at the plasma membrane of arteries and veins — either by receptor stimulation or depolarization — leads to a decrease in the approximately 10,000 fold electrochemical gradient for Ca2+, chiefly by increasing the permeability to extracellular Ca2+ and by mobilizing intracellular stores of Ca2+. Voltage changes that accompany production of vascular tone lead to activation of Ca2+ channels (Nelson et al., 1988). Vasoconstrictor agonists cause receptor mediated stimulation of G-proteins, which in turn leads to activation of phospholipase C and the generation of two key intracellular messengers — inositol 1,4,5 trisphosphate (IP3) and diacylglycerol (DAG) (Berridge, 1993). DAG promotes the activation of protein kinase C to a highly Ca2+ -sensitive form leading to phosphorylation of a number of intracellular targets including K+ and Ca2+ ion channels involved in the production of smooth muscle tone (Bonev and Nelson, 1993; Fish et al., 1988).

Keywords

Smooth Muscle Sarcoplasmic Reticulum Internal Store Smooth Muscle Tone Rabbit Aorta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Regent Laporte
    • 1
  • Ismail Laher
    • 1
  1. 1.Department of PharmacologyUniversity of VermontBurlingtonUSA

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