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The Vascular Ornithine Decarboxylase/Polyamine System in Deoxycorticosterone Acetate-Salt Hypertension

  • E. E. Soltis
  • P. S. Newman
  • M. E. Brown
  • J. L. Trowbridge
  • H. Guo
  • S. Arcot
  • J. W. Olson
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)

Abstract

The present study was conducted to assess the time course of alterations in vascular polyamines and the associated changes in vascular structure and function in the deoxycorticosterone acetate-salt (DOCA-salt) rat. Cellular and molecular mechanisms involved in these alterations were examined in mesenteric resistance arteries at 1, 3, and 6 weeks of DOCA-salt treatment. Blood pressure increased progressively over the 6 week treatment period. Vascular polyamine contents and ornithine decarboxylase (ODC) activity were increased at all 3 time points in DOCA-salt rats. In contrast to ODC activity, ODC mRNA content was unaltered at 1 and 3 weeks and was significantly decreased at 6 weeks in DOCA-salt rats. Significant alterations in vascular structure and function accompanied the changes in the ODC/polyamine system. Coupled with previous reports from our laboratory, these data suggest that alterations in the ODC/polyamine system and the subsequent elevation in polyamines are required for the vascular changes observed in DOCA-salt hypertension.

Keywords

Ornithine Decarboxylase Polyamine Content Liquid Scintillation Detection Mesenteric Resistance Artery Mesenteric Vasculature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • E. E. Soltis
    • 1
  • P. S. Newman
    • 1
  • M. E. Brown
    • 1
  • J. L. Trowbridge
    • 1
  • H. Guo
    • 1
  • S. Arcot
    • 1
  • J. W. Olson
    • 1
  1. 1.Division of Pharmacology and Experimental TherapeuticsUniversity of KentuckyLexingtonUSA

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