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Exercise Training Augments EDRF (Nitric Oxide) Synthesis in Skeletal Muscle Arterioles

  • Akos Koller
  • Dong Sun
  • An Huang
  • Gabor Kaley
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)

Abstract

Recent in vivo (5,7,18) and in vitro (21,22) studies provide ample evidence for the participation of EDRF (nitric oxide) in the mediation of the action of various vasoactive substances and in the basal regulation of microvascular tone. Despite these findings however, there are only few, if any, studies suggesting a role for EDRF/NO in the various autoregulatory responses of microvessels in skeletal muscle. For example, previously we found that in rat cremasteric arterioles reactive hyperemia and flow dependent dilation are mediated by another endothelium-derived agent, namely prostaglandin(s), rather than nitric oxide (8,9,10). A contribution of prostaglandins in exercise-induced vasodilation was also reported in human forearm experiments (24). No definitive role for EDRF, however, was found in the development of functional hyperemia in the cat hind limb (19), whereas in dogs a role for EDRF was shown in phrenic nerve stimulation-induced hyperemia in the diaphragm (6) and in skeletal muscle hyperemia to acute exercise (21).

Keywords

Nitric Oxide Wall Shear Stress Perfusate Flow Gracilis Muscle Endothelium Dependent Dilation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Akos Koller
    • 1
  • Dong Sun
    • 1
  • An Huang
    • 1
  • Gabor Kaley
    • 1
  1. 1.New York Medical CollegeValhallaUSA

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