Advertisement

Molecular and Cellular Mechanisms of Lens Growth Control during Development and Aging

  • Y. Courtois
  • C. Arruti
  • P. R. Blanquet
  • J. C. Jeanny
  • F. Mascarelli
  • J. Treton
Chapter
Part of the Perspectives in Vision Research book series (PIVR)

Abstract

Studies on the regulation of lens growth during development and aging have led to the identification of external signals that may be provided during the whole life span by surrounding tissues, retina, vitreous, or iris. These signals may be positive— i.e., they may be involved in triggering cell division and cell elongation—or negative—i.e., they can prevent cell division in order to keep the growth of the lens under control. In addition, they should be aimed at some precise area of the lens epithelium or fibers, since lens growth depends on stimulation of cells at the lens periphery. They should also be able to cross the lens capsule, which completely surrounds the lens. It has been proposed that polypeptide growth factors can fulfill this function in the eyes. The purpose of this chapter is to show, on the basis data obtained in our laboratory as well as in other laboratories, that a family of growth factors— fibroblast growth factors (FGF, formerly called EDGF)—can control lens growth.

Keywords

Basic Fibroblast Growth Factor Derive Growth Factor Lens Capsule Vimentin Filament Maximum Life Span Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Altaian, P. L., and Dinner, D. S., eds., 1972, Biology Data Book, Federation of American Societies for Experimental Biology., Bethesda.Google Scholar
  2. Arruti, C., and Courtois, Y., 1978, Morphological changes and growth stimulation of bovine epithelial lens cells by a retinal extract in vitro, Exp. Cell Res. 177:283–292.CrossRefGoogle Scholar
  3. Arruti, C., Barritault, D., and Courtois, Y., 1981, Is there a ubiquitous growth factor in the eye? Differentiation 18:29–42.PubMedCrossRefGoogle Scholar
  4. Arruti, C., Cirillo, A., and Courtois, Y., 1985, An eye-derived growth factor regulates epithelial cell proliferation in cultured lens, Differentiation 28:286–290.PubMedCrossRefGoogle Scholar
  5. Arruti, C., Mascarelli, F., and Courtois, Y., 1989, The effect of eye-derived growth factor (EDGFs) on methionine incorporation in the different cell populations in bovine adult lens in organ culture, Exp. Eye Res. 48:177–186.PubMedCrossRefGoogle Scholar
  6. Blanquet, P., and Courtois, Y., 1989, Differential assemblage of the basal membrane cytoskeleton, Exp. Eye Res. 48:187–207.PubMedCrossRefGoogle Scholar
  7. Blanquet, P., Paillard, S., and Courtois, Y., 1989a, Influence of fibroblast growth factor on phosphorylation and activity of a 34 kDa lipocortin-like protein in bovine epithelial lens cells, FEBS Lett.229:183–187.CrossRefGoogle Scholar
  8. Blanquet, P., Patte, C., Fayein, N., and Courtois, Y., 1989b, Identification and isolation from bovine epithelial lens of two basic fibroblast growth factor receptors that possess bFGF-enhanced phosphorylation activities, Biochem. Biophys. Res. Commun. 160:1124–1131.PubMedCrossRefGoogle Scholar
  9. Brugge, J. S., 1986, The p35/p36 substrates of protein-tyrosine kinase as inhibitors of phospholipase A2, Cell 46:149–150.PubMedCrossRefGoogle Scholar
  10. Chamberlain, C. G., and McAvoy, J. W. ,1987, Evidence that fibroblast growth factor promotes lens fibre differentiation, Curr. Eye Res. 6:1165–1168.PubMedCrossRefGoogle Scholar
  11. Chevallier, B., Loret, C., Barritault, D., Courty, J., Moenner, M., Lagente, O., and Courtois, Y., 1985, Bovine retina contains growth factor activities with different affinity to heparin: Eye-derived growth factor I, II, II, Biochimie 67:265–269.PubMedCrossRefGoogle Scholar
  12. Cirillo, A., Arruti, C., and Courtois, Y., 1985, A retina derived growth factor regulates epithelial cell proliferation in cultured lens, Differentiation 28:286–290.PubMedCrossRefGoogle Scholar
  13. Halley, C., Courtois, Y., and Laurent, M., 1988, “Nucleotide sequence of acidic fibroblast growth factor CDNA, Nucl. Ac. Res. 16:109–113.”CrossRefGoogle Scholar
  14. Huang, S. S., and Huang, Y.S., 1986, Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activitY., Biochemistry 261:9568–9571.Google Scholar
  15. Jeanny, J. C., Fayein, N., Moenner, M., Chevallier, B., Barritault, D., and Courtois, Y., 1987, Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factor to mouse embryonic eye basement membranes, Exp. Cell Res. 171:63–75.PubMedCrossRefGoogle Scholar
  16. Lord, R. D., 1959, The lens as an indication of age in cotton tail rabbits, WM. Mgmt. 23:338–360.Google Scholar
  17. Mascarelli, F., Raulais, D., and Courtois, Y., 1989, Fibroblast growth factor—rod outer segment interaction: High and low affinity binding sites and release of phosphorylated acidic FUF by light kinase C dependent phosphorylation, EMBO J.8:2265–2273.PubMedGoogle Scholar
  18. Piatigorsky, J., 1981, Lens differentiation in vertebrates. A review of cellular and molecular features, Differentiation 19:134–153.PubMedCrossRefGoogle Scholar
  19. Plouet, J., Mascarelli, F., Loret, M. D., Faure, J. P., and Courtois, Y., 1988, Regulation of eye derived growth factor binding to membranes by light ATP, GTP in photoreceptors outer segments, EMBO J.7:373–376.PubMedGoogle Scholar
  20. Raulais, D., Mascarelli, F., Counis, M. F., and Courtois, Y., 1987, Characterization of acidic and basic fibroblast growth factors in brain, retina and vitreous chick embryo, Biochem. Biophys. Res. Commun. 146:478–486.PubMedCrossRefGoogle Scholar
  21. Treton, J., and Courtois, Y., 1989, Evidence for a relationship between longevity of mammalian species and a lens growth parameter, Gerontology (in press).Google Scholar
  22. Uhlrich, S., Lagente, O., Lenfant, M., and Courtois, Y., 1986, Effects of Heparin on the stimulation of nonvascular cells by human acidic and basic FGF, Biochem. Biophys. Res. Commun. 137:1205–1213.PubMedCrossRefGoogle Scholar
  23. Vlodavsky, I., Folkman, J., Sullivan, R., Fridman, R., Ishai-Michaeli, R., Sasse, J., and Klagsbrun, M., 1987, Endothelial cell derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix, Proc. Natl. Acad. Sci. U.S.A. 84:2292–2296.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Y. Courtois
    • 1
  • C. Arruti
    • 1
  • P. R. Blanquet
    • 1
  • J. C. Jeanny
    • 1
  • F. Mascarelli
    • 1
  • J. Treton
    • 1
  1. 1.Gerontology Research UnitParisFrance

Personalised recommendations