Intrauterine Infections

  • Dagmar K. Kalousek
  • Naomi Fitch
  • Barbara A. Paradice


Our understanding of the role of intrauterine infection in the etiology of pregnancy loss has been seriously hampered by the large number of microorganisms associated with placental and fetal pathology. Difficulties in accurately diagnosing clinical disease in the mother, due to the fact that many infections have nonspecific symptoms or that the mother may have an asymptomatic disease, have also interfered with our investigations. Microbiologic diagnoses are further complicated by the fact that many putative fetal pathogens may reside normally in the maternal genital tract as commensal flora (e.g., group B streptococci, mycoplasmas). To make it more complex, obtaining appropriate, noncontaminated embryonic, fetal, and placental samples for culture in both early and late pregnancy loss is difficult. Special culture or detection techniques are required for some organisms (e.g., Chlamydia, Mycoplasma) and interpretations of microbial growth in cultures are often complicated by the presence of other microorganisms.


Human Immunodeficiency Virus Amniotic Fluid Spontaneous Abortion Amniotic Membrane Rubella Virus 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dagmar K. Kalousek
    • 1
  • Naomi Fitch
    • 2
  • Barbara A. Paradice
    • 3
  1. 1.Department of PathologyThe University of British Columbia and BC Children’s HospitalVancouverCanada
  2. 2.Department of Pathology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General HospitalThe University of British ColumbiaMontrealCanada
  3. 3.Embryopathology UnitBC Children’s HospitalVancouverCanada

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