• Edward D. Frohlich


Hypertension is persistent elevation of the systolic and/or diastolic arterial pressure on either a primary (essential) or secondary basis. Uncontrolled, such pressure elevations lead to functional impairment of target organs—heart, brain, and kidneys—and accompanying morbidity and mortality.


Angiotensin Converting Enzyme Essential Hypertension Calcium Antagonist Sexual Dysfunction Angiotensin Converting Enzyme Inhibitor 
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  1. 1.
    Drizd T, Dannenberg A, Engel A. Blood pressure levels in persons 18–74 years of age in 1976–80, and trends in 18. blood pressure from 1960–80 in the United States. Vital Health Stat 11 1986.Google Scholar
  2. 2.
    The Joint National Committee on the Detection, Evalu- 19. ation and Treatment of High Blood Pressure: the 1988 report of the Joint National National Committee on Detection, Evaluation and Treatment of High Blood 20. Pressure. Arch Intern Med 1988; 148: 1023–1038.CrossRefGoogle Scholar
  3. 3.
    Genest J, Larochelle P, Kuchel O, et al. Hypertension in the elderly: atheroarteriosclerotic hypertension. In: 21. Genest J, Kuchel O, Hamet P, et al, eds. Hypertension: Physiopathology and Treatment. 2nd ed. New York, 22. NY: McGraw-Hill International Book Co; 1983: 913–921.Google Scholar
  4. 4.
    Kannel WB, Doyle JT, Ostfeld AM, et al (Atherosclerosis Study Group). Optimal resources for primary prevention of atherosclerotic diseases. Circulation 1984; 70 (suppl): 157A–205A.CrossRefGoogle Scholar
  5. 5.
    Kannel WB. Implications of Framingham study data for treatment of hypertension: impact of other risk factors. In: Laragh HG, Buhler FR, Seldin DW, eds. Frontiers of Hypertension Research. New York, NY: Springer-Verlag NY Inc; 1981: 17–21.CrossRefGoogle Scholar
  6. 6.
    Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the Hypertension Detection and Follow-Up Program, III: reduction in stroke incidence among persons with high blood pressure. JAMA 1982; 247: 633–638.CrossRefGoogle Scholar
  7. 7.
    National Heart Foundation of Australia. Treatment of mild hypertension in the elderly: report by the Management Committee. Med J Aust 1981; 2: 398–402.Google Scholar
  8. 8.
    Amery A, Birkenhager W, Brixho P, et al. Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly Trial. Lancet 1985;1:1349–1354.Google Scholar
  9. 9.
    Kannel WB. Prevalence and natural history of electrocardiographic left ventricular hypertrophy. Am J Med 1983; 75 (3A): 4–11.PubMedCrossRefGoogle Scholar
  10. 10.
    Kannel WB, Castelli WP, McNamara PM, et al. Role of blood pressure in the development of congestive heart failure: the Framingham Study. N Engl J Med 1972; 207: 781–787.CrossRefGoogle Scholar
  11. 11.
    Kannel WB, Dawber TR, Sorkie P, et al. Components of blood pressure and risk of atherothrombotic brain infarction: the Framingham Study. Stroke 1976; 7: 327–331.PubMedCrossRefGoogle Scholar
  12. 12.
    Kannel WB, Gordon T. Evaluation of the cardiovascular risk in the elderly: the Framingham Study. Bull NYAcad Med 1978; 54: 573–591.Google Scholar
  13. 13.
    Hughes G, Schnaper HW. The Isolated Systolic Hyper- 34. tension in the Elderly Program. Int J Ment Health 1982; 2: 76–97.Google Scholar
  14. 14.
    WHO Expert Committee. Arterial Hypertension. WHO Tech Rep Ser 1978.Google Scholar
  15. 15.
    Shekelle RB, Ostfeld AM, Klawans HL Jr. Hypertension and risk of stroke in an elderly population. Stroke 1974; 5: 71–75.PubMedCrossRefGoogle Scholar
  16. 16.
    European Working Party on High Blood Pressure in the Elderly: Antihypertensive therapy in patients above age 60 with systolic hypertension. Clin Exp Hypertens A 1982; 4: 1151–1176.Google Scholar
  17. 17.
    Amery A, Hansson L, Andren L, et al. Hypertension in the elderly. Acta Med Scand 1981; 210: 221–229.PubMedCrossRefGoogle Scholar
  18. 18.
    Frohlich ED: Multicenter clinical trials: potential influence of consumer education. Hypertension 1987; 9 (suppl 3): 75–79.Google Scholar
  19. 19.
    Health and Nutritional Examination Study (HANES). Blood pressure levels of persons 60–74. Vital Health Stat2 1977.Google Scholar
  20. 20.
    Working Group on Hypertension in the Elderly. Statement on hypertension in the elderly. JAMA 1986; 256: 70–74.CrossRefGoogle Scholar
  21. 21.
    Frohlich ED. Hypertension in the elderly. Curr Probl Cardiol 1988; 13: 313–367.PubMedCrossRefGoogle Scholar
  22. 22.
    Frohlich ED. Mechanisms contributing to high blood pressure. Ann Intern Med 1983; 98: 709–714.PubMedGoogle Scholar
  23. 23.
    Dzau VJ, Gibbons GH. Autocrine paracrine mechanisms of vascular myocytes in systemic hypertension. Am J Cardiol 1987; 60: 99–103.CrossRefGoogle Scholar
  24. 24.
    Re RN. Cellular mechanisms of growth in cardiovascular tissue. Am J Cardiol 1987; 60: 104–109.CrossRefGoogle Scholar
  25. 25.
    Frohlich ED, ed. Pathophysiology: Altered Regulatory Mechanisms in Disease. 3rd ed. Philadelphia, Pa: JB Lippincott; 1984.Google Scholar
  26. 26.
    Frohlich ED, Tarazi RC, Dustan HP. Clinical-physiological correlations in the development of hypertensive heart disease. Circulation 1971; 44: 446–455.PubMedCrossRefGoogle Scholar
  27. 27.
    Lakatta EG. Alterations in the cardiovascular system that occur in advanced age. FASEB J 1979; 38: 163–167.Google Scholar
  28. 28.
    Dunn FG, Frohlich ED. Hypertension and angina pectoris. In: Yu PN, Goodwin JF, eds. Progress in Cardiology. Philadelphia, Pa: Lea & Febiger, 1978: 163–196.Google Scholar
  29. 29.
    Levy D, Anderson KM, Savage DD, et al. Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors-the Framingham Study. Ann Intern Med 1988; 108: 7–13.PubMedGoogle Scholar
  30. 30.
    Frohlich ED, Messerli FH, Reisin E, et al. The problem of obesity and hypertension. Hypertension 1983; 5 (suppl 3): 71–78.Google Scholar
  31. 31.
    Frohlich ED. Achievements in hypertension: a 25-year overview. J Am Coll Cardiol 1983; 1: 225–239.PubMedCrossRefGoogle Scholar
  32. 32.
    Oren S, Grossman E, Messerli FH, et al. High blood pressure: side effects of drugs, poisons, and food. In: Ram CV, ed. Cardiology Clinics of North America; 1988; 6,2:467–474. Philadelphia, Pa: WB Saunders Co. In press.Google Scholar
  33. 33.
    Weiss NS. Relation of high blood pressure to headache, epistaxis, and selected other symptoms: the United States Health Examination Survey of Adults. N Engl J Med 1972; 287: 631.PubMedCrossRefGoogle Scholar
  34. 34.
    Messerli FH, Ventura HO, Amodeo C. Osler’s maneuver and pseudohypertension. N Engl J Med 1985; 312: 1548–1551.PubMedCrossRefGoogle Scholar
  35. 35.
    Tarazi RC, Miller A, Frohlich ED, et al. Electrocard iographic changes reflecting left atrial abnormality in hypertension. Circulation 1966; 34: 818–822.PubMedCrossRefGoogle Scholar
  36. 36.
    Dunn FG, Chandraratna PN, Basta LL, et al. Patho physiologic assessment of hypertensive heart disease with echocardiography. Am J Cardiol 1977; 39: 789 795.Google Scholar
  37. 37.
    Dreslinsky GR, Frohlich ED, Dunn FG, et al. Echocar-diographic diastolic ventricular abnormality in hypertensive heart disease: atrial emptying index. Am J Cardiol 1981; 47: 1087–1090.CrossRefGoogle Scholar
  38. 38.
    Inouye I, Massie B, Loge D, et al. Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol 1984; 53: 120–126.PubMedCrossRefGoogle Scholar
  39. 39.
    Messerli FH, Frohlich ED, Dreslinski GR, et al. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med 1980; 93: 817–821.PubMedGoogle Scholar
  40. 40.
    Kobrin I, Frohlich ED, Ventura HO, et al. Renal involvement follows cardiac enlargement in essential hypertension. Arch Intern Med 1986; 146: 272–276.PubMedCrossRefGoogle Scholar
  41. 41.
    Frohlich ED, Gifford R Jr, Horan M, et al. Nonpharmacologic approaches to the control of high blood pressure: report of the Subcommittee on Nonpharmacologic Therapy of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure, 1984. Hypertension 1986; 8: 444–467.CrossRefGoogle Scholar
  42. 42.
    Stamler R, Stamler J, Grimm R: Nutritional therapy for high blood pressure: final report of a four-year randomized control trial—the hypertension control program. JAMA 1987; 257: 1484–1491.PubMedCrossRefGoogle Scholar
  43. 43.
    Dustan HP, Page IH, Tarazi RC, et al. Arterial pressure responses to discontinuing antihypertensive drug treatment. Circulation 1968; 37: 370–379.PubMedCrossRefGoogle Scholar
  44. 44.
    Frohlich ED. Hypertension. In: Rackel R, ed. Conn’s Current Therapy. Philadelphia, Pa: WB Saunders Co. 1989, pp 225–241Google Scholar

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© Springer Science+Business Media New York 1990

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  • Edward D. Frohlich

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