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Cellular Aging

  • Thomas H. Norwood

Abstract

The level of investigative activity into the mechanisms of aging at the cellular and molecular level has increased dramatically during the past two to three decades. While these efforts certainly have yielded a wealth of descriptive information and some fundamental changes in our perception of the aging process, definitive knowledge of the cause or causes of aging remains elusive. Investigative efforts in the area of cellular aging address a number of questions, the answers to which are only beginning to emerge. For example, it is not known if all cell populations in the body are vulnerable to aging, or if the nature of the aging process is similar in all cell populations in the body. Some scientists have suggested that the rate of aging is determined by one or a few critical cell populations; an alternative notion is that the manifestations of aging are the summation of subtle decrements of function in most or all of the cell populations in the body. Also, the role of aging at the cellular level in the pathogenesis of age-associated diseases, such as arteriosclerotic vascular disease and many carcinomas, remain, for the most part, speculative. While definitive answers to the questions posed above are not forthcoming at the present time, there is enough information to permit some speculation about future directions that may be pursued in the area of cellular aging. In this chapter, the current status of cellular aging will be discussed at a level that will provide geriatricians with a foundation of knowledge to assist them in following future developments in the field of basic gerontology.

Keywords

Cellular Aging Senescent Cell Fibroblast Culture Maximum Life Span Human Diploid Cell Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Thomas H. Norwood

There are no affiliations available

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