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Gastrointestinal Blood Flow

  • J. W. Kiel
  • A. P. Shepherd
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 107)

Abstract

Despite the development of numerous methods for measuring gastrointestinal blood flow, important physiological questions remain unanswered regarding the gastrointestinal circulation, its regulation, and its relationship to gastrointestinal function. For example, investigators of the gastrointestinal circulation generally agree that alterations in blood flow participate in the etiology of a variety of gastrointestinal disorders ranging from gastric ulcers to necrotizing enterocolitis. However, the role of blood flow in maintaining mucosal integrity in the stomach and intestine is still poorly understood.

Keywords

Laser Doppler Flowmetry Reactive Hyperemia Mucosal Blood Flow Serosal Surface Gastric Mucosal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shepherd, A. P., G.L. Riedel, J.W. Kiel, D.J. Haumschild, and L.C. Maxwell. 1987. Evaluation of an infrared laser-Doppler blood flowmeter. Am J Physiol 252:G832–G839.PubMedGoogle Scholar
  2. 2.
    Shepherd, A.P. and G.L. Riedel. 1982. Continuous measurement of intestinal mucosal blood flow by laser-Doppler velocimetry. Am J Physiol 242:G668–G672.PubMedGoogle Scholar
  3. 3.
    Bonner, R. F., T.R. Clem, P. D. Bowen, and R.L. Bowman. 1981. Laser-Doppler continuous real-time monitor of pulsatile and mean blood flow in tissue microcirculation. In Scattering Techniques Applied to Suptra-molecular and Nonequilibrium Systems, Chen, S.H., Chu, B., Nossal R., eds. New York: Plenum, vol. 73, pp 685–702 (NATO AS 1 Ser B).CrossRefGoogle Scholar
  4. 4.
    Ahn, H., J. Lindhagen, G.E. Nilsson, E.G. Salerud, M. Jodal, and O. Lundgren. 1985. Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 88:951–957.PubMedGoogle Scholar
  5. 5.
    Ahn, H., K. Johansson, O. Lundgren, and G.E. Nilsson. 1987. In vivo evaluation of signal processors for laser Doppler tissue flowmeters. Med Biol Eng Comput 25:207–211.PubMedCrossRefGoogle Scholar
  6. 6.
    Ahn, H., J. Lindhagen, G.E. Nilsson, P. A. Öberg, and O. Lundgren. 1986. Assessment of blood flow in the small intestine with laser Doppler flowmetry. Scand J Gastroenterol 21(7):863–870.PubMedCrossRefGoogle Scholar
  7. 7.
    Kvietys, P. R., A.P. Shepherd, and D.N. Granger. 1985. Laser-Doppler, H2 clearance, and microsphere estimates of mucosal blood flow. Am J Physiol 249:G221–G227.PubMedGoogle Scholar
  8. 8.
    Rotering, R. H., K. R. Larsen, J. A. Dixon, and F.G. Moody. 1981. The measurement of canine gastric mucosal blood flow with a laser Doppler velocimeter. Physiologist 24(4):15 (abstract).Google Scholar
  9. 9.
    Ahn, H., K. Johansson, J. Lindhagen, and E.G. Salerud. 1984. Laser Doppler flowmetry in the assessment of gastric blood flow in man. Scand J Gastroenterol 19 (Suppl 98): 33.Google Scholar
  10. 10.
    Murakami, M., H. Saida, M. Seki, M. Inada, and T. Miyake. 1984. Measurements of mucosal blood flow of the esophagus and stomach in humans: regional differences and changes with aging. Gastroenterology 86:1191 (abstract).Google Scholar
  11. 11.
    Saita, H., M. Murakami, M. Seki, and T. Miyake. 1984. Evaluation of the measurement of gastric mucosal blood flow by laser-Doppler velocimetry in rats. Gastroenterology 86:1228 (abstract).Google Scholar
  12. 12.
    Kiel, J. W., G.L. Riedel, G.R. DiResta, and A.P. Shepherd. 1985. Gastric mucosal blood flow measured by laser-Doppler velocimetry. Am J Physiol 249:G539–G545.PubMedGoogle Scholar
  13. 13.
    Kiel, J. W., G.L. Riedel, and A.P. Shepherd. 1987. Autoregulation of canine gastric mucosal blood flow. Gastroenterology 93:12–20.PubMedGoogle Scholar
  14. 14.
    Bonner, R., and R. Nossal. 1981. Model for laser-Doppler measurements of blood flow in tissue. Appl Optics 20:2097–2107.CrossRefGoogle Scholar
  15. 15.
    Johansson, K., H. Ahn, J. Lindhagen, and O. Lundgren. 1987. Tissue penetration and measuring depth of laser Doppler flowmetry in the gastrointestinal application. Scand J Gastroenterol 22:1081–1088.PubMedCrossRefGoogle Scholar
  16. 16.
    Shepherd, A. P., G.L. Riedel, L.C. Maxwell, and J.W. Kiel. 1984. Selective vasodilators redistribute intestinal blood flow and depress oxygen uptake. Am J Physiol 247:G377–G384.PubMedGoogle Scholar
  17. 17.
    Granger, D. N., J.D. Valleau, R. E. Parker, R.S. Lane, and A.E. Taylor. 1978. Effects of adenosine on intestinal hemodynamics, oxygen delivery, and capillary fluid exchange. Am J Physiol 235: H707–H719.PubMedGoogle Scholar
  18. 18.
    Shepherd, A. P., and G.L. Riedel. 1984. Differences in reactive hyperemia between intestinal mucosa and muscularis. Am J Physiol 247:G617–G622.PubMedGoogle Scholar
  19. 19.
    Kiel, J. W., G.L. Riedel, and A.P. Shepherd. 1987. Local control of canine gastric mucosal blood flow. Gastroenterology 93:1041–1053.PubMedGoogle Scholar
  20. 20.
    Shepherd, A. P., and G.L. Riedel. 1985. Laser-Doppler blood flowmetry of intestinal mucosal hyperemia induced by glucose and bile. Am J Physiol 248:G393–G397.PubMedGoogle Scholar
  21. 21.
    Holm-Rutili, L., and T. Berglindh. 1986. Pentagastrin and gastric mucosal blood flow. Am J Physiol 250: G575–G580.PubMedGoogle Scholar
  22. 22.
    Chou, C. C., C.P. Hsich, Y.M. Yu, P. Kvietys, L.C. Yu, R. Pittman, and J.M. Dabney. 1976. Localization of mesenteric hyperemia during digestion in dogs. Am J Physiol 230:583–589.PubMedGoogle Scholar
  23. 23.
    Gana, T.J., R. Huhlewch, and J. Koo. 1987. Focal gastric mucosal blood flow by laserDoppler and hydrogen gas clearance: a comparative study. J Surg Res 43:337–343.PubMedCrossRefGoogle Scholar
  24. 24.
    DiResta, G. R., J.W. Kiel, G.L. Riedel, P. Kaplan, and A.P. Shepherd. 1987. Hybrid blood flow-probe for simultaneous H2 clearance and laser-Doppler velocimetry. Am J Physiol 16:G573–G581.Google Scholar
  25. 25.
    Ahn, H., J. Lindhagen, and O. Lundgren. 1986. Measurement of colonic blood flow with laser Doppler flowmetry. Scand J Gastroenterol 21(7):871–880.PubMedCrossRefGoogle Scholar
  26. 26.
    Ahn, H., K. Johansson, and J. Lindhagen. 1986. Local blood flow changes in association with proximal gastric vagotomy. Scand J Gastroenterol 21(8):961–964.PubMedCrossRefGoogle Scholar
  27. 27.
    Johnson, J. M., W.F. Taylor, A.P. Shepherd, and M. A. Park. 1984. Laser-Doppler measurement of skin blood flow: a comparison with plethysmograph. J Appl Physiol 56:798–803.PubMedCrossRefGoogle Scholar
  28. 28.
    Nilsson, G.E. 1984. Signal processor for laser Doppler tissue flowmeters. Med Biol Eng Comput 22:343–348.PubMedCrossRefGoogle Scholar
  29. 29.
    Nilsson, G.E., T. Tenland, and P.Å. Öberg. 1980. Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng BME-27:597–604.CrossRefGoogle Scholar
  30. 30.
    Demling, L., and F. Wachsmann. 1961. A new method for measuring blood flow variations in the gastric mucosa. Ger Med Monthly 6:189–191.Google Scholar
  31. 31.
    Holm-Rutili, L., and K.J. Öbrink. 1985. Rat gastric mucosal microcirculation in vivo. Am J Physiol 248:G741–G746.PubMedGoogle Scholar
  32. 32.
    Salerud, E. G., and G.E. Nilsson. 1986. Integrating probe for tissue laser Doppler flowmeters. Med Biol Eng Comput 24:415–419.PubMedCrossRefGoogle Scholar
  33. 33.
    Shepherd, A.P. 1980. Intestinal blood flow autoregulation during foodstuff absorption. Am J Physiol 239:H156–H162.PubMedGoogle Scholar
  34. 34.
    Perry, M. A., D. Murphree, and D.N. Granger. 1982. Oxygen uptake as a determinant of gastric blood flow autoregulation. Dig Dis Sci 27:675–679.PubMedCrossRefGoogle Scholar
  35. 35.
    Selkurt, E. E., C. F. Rothe, and D. Richardson. 1964. Characteristics of reactive hyperemia in the canine intestine. Circ Res 15:532–544.PubMedCrossRefGoogle Scholar
  36. 36.
    Perry, M. A., G. B. Bulkley, P.R. Kvietys, and D.N. Granger. 1982. Regulation of oxygen uptake in resting and pentagastrin-stimulated canine stomach. Am J Physiol 242:G565–G569.PubMedGoogle Scholar
  37. 37.
    Moody, F.G. 1967. Gastric blood flow and acid secretion during direct intraarterial histamine administration. Gastroenterology 52:216–224.PubMedGoogle Scholar
  38. 38.
    Folkow, B., D.H. Lewis, O. Lundgren, S. Mellander, and I. Wallentin. 1964. The effect of graded vasoconstrictor fibre stimulation on the intestinal resistance and capacitance vessels. Acta Physiol Scand 61:445–457.PubMedCrossRefGoogle Scholar
  39. 39.
    Jansson, G., M. Kampp, O. Lundgren, and J. Martinson. 1966. Studies on the circulation of the stomach. Acta Physiol Scand 68 (Suppl 277):91.Google Scholar
  40. 40.
    Shepherd, A.P. 1977. Myogenic responses of intestinal resistance and exchange vessels. Am J Physiol 233:H547–H554.PubMedGoogle Scholar
  41. 41.
    Lutz, J., and J. Biester. 1971. Die Reaktion der Magengefässe auf venöse und arterielle Druckreize und ihr Vergleich mit Werten von Milz- und Intestinalstrombahn. Pflügers Arch 330:230–242.PubMedCrossRefGoogle Scholar
  42. 42.
    Shepherd, A.P., and H.J. Granger. 1973. Autoregulatory escape in the gut: a systems analysis. Gastroenterology 65:77–91.PubMedGoogle Scholar
  43. 43.
    Folkow, B. 1964. Description of the myogenic hypothesis. Circ Res 14 (Suppl 1):279–285.Google Scholar
  44. 44.
    Johnson, P.C. 1967. Autoregulation of blood flow in the intestine. Gastroenterology 52:435–441.PubMedGoogle Scholar
  45. 45.
    Johnson, P.C. 1965. Effect of venous pressure on mean capillary pressure and vascular resistance in the intestine. Circ Res 16:294–300.PubMedCrossRefGoogle Scholar
  46. 46.
    Davis, M.J., and R.W. Gore. 1985. Capillary pressures in rat intestinal muscle and mucosal villi during venous pressure elevation. Am J Physiol 249:H174–H187.PubMedGoogle Scholar
  47. 47.
    Kiel, J. W., and A.P. Shepherd. 1989. Effects of sympathetic stimulation on gastric blood flow and oxygen uptake. FASEB J 3:A714 (abstract).Google Scholar
  48. 48.
    Shepherd, A. P., and G.L. Riedel. 1988. Intramural distribution of intestinal blood flow during sympathetic stimulation. Am J Physiol 255:H1091–H1095.PubMedGoogle Scholar
  49. 49.
    Guth, P. H. and E. Smith. 1975. Escape from vasoconstriction in the gastric microcirculation. Am J Physiol 228:1893–1895.Google Scholar
  50. 50.
    Guth, P.H., and E. Smith. 1975. Neural control of gastric mucosal blood flow in the rat. Gastroenterology 69:935–940.PubMedGoogle Scholar
  51. 51.
    Archibald, L. H., F.G. Moody, and M. Simons. 1974. Effect of isoproterenol on canine gastric acid secretion and blood flow. Surg For 25:409–411.Google Scholar
  52. 52.
    Rotering, R. H., J. A. Dixon, G. A. Holloway, and D.W. McCloskey. 1982. A comparison of the HeNe laser and ultrasound Doppler systems in the determination of viability of ischemic canine intestine. Ann Surg 196:705–708.PubMedCrossRefGoogle Scholar
  53. 53.
    Chung, R.S., D. Bruch, and J. Dearlove. 1988. Endoscopic measurement of gastric mucosal blood flow by laser Doppler velocimetry: effect of chronic esophogeal variceal sclerosis. Am Surg 54:116–120.PubMedGoogle Scholar
  54. 54.
    Kvernebo, K., O.C. Lunde, E. Stranden, and S. Larsen. 1986. Human gastric blood circulation evaluated by endoscopic laser Doppler flowmetry. Scand J Gastroenterol 21:685–692.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • J. W. Kiel
  • A. P. Shepherd

There are no affiliations available

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