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Transducing Systems in the Control of Human Thyroid Cell Function, Proliferation and Differentiation

  • J. E. Dumont
  • A. Lefort
  • F. Libert
  • M. Parmentier
  • E. Raspé
  • S. Reuse
  • C. Maenhaut
  • P. Roger
  • B. Corvilain
  • E. Laurent
  • J. Mockel
  • F. Lamy
  • J. Van Sande
  • G. Vassart
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 261)

Abstract

Our laboratory has been involved in the study of thyroid regulation at the cellular level for many years. The complex picture emerging from these studies leads to conclusions of general relevance. The regulation of the thyroid cell was once a classical example of the concept one hormone — one cell type — one intracellular secondary messenger with its pleiotypic effects. It should now rather be considered as a network of crosslinked regulatory steps where the extracellular and intracellular signal-molecules act on their receptors as bits of information in an electronic circuit, i.e., express on/off regulations with no definite general physiological meaning per se. Such networks differ from one cell type to another and for a given cell type from one species to another. In the case of the thyroid many apparent discrepancies in the literature are explained if this is taken into account. In this presentation, we wish to draw mainly on the results of our group to illustrate this point with regard to the regulation of function, proliferation and differentiation of the thyroid cell.

Keywords

Thyroid Cell Human Thyroid FRTL5 Cell Thyroid Hormone Synthesis Thyroid Stimulate Immunoglobulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. E. Dumont
    • 1
  • A. Lefort
    • 1
  • F. Libert
    • 1
  • M. Parmentier
    • 1
  • E. Raspé
    • 1
  • S. Reuse
    • 1
  • C. Maenhaut
    • 1
  • P. Roger
    • 1
  • B. Corvilain
    • 1
  • E. Laurent
    • 1
  • J. Mockel
    • 1
  • F. Lamy
    • 1
  • J. Van Sande
    • 1
  • G. Vassart
    • 1
  1. 1.Institute of Interdisciplinary Research (IRIBHN)Free University of Brussels, School of MedicineBrusselsBelgium

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