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Stable Recombinant Avirulent Salmonella Vaccine Strains

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Immunobiology of Proteins and Peptides V

Abstract

All infectious disease agents have specific mechanisms to colonize , invade , and overcome the host. By use of gene cloning and genetic and biochemical techniques , it is possible to elucidate these mechanisms in biochemical terms as well as to understand the biology by which pathogens accomplish these feats . Once these mechanisms are understood, the information can be used to design novel strategies to immunize the host to prevent infection and disease by the pathogen. Since most pathogens colonize on and invade through a mucosal surface, it is appropriate to develop an immunization strategy that elicits a mucosal immune response as well as production of serum IgG and a cellular immune response.

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Author information

Authors and Affiliations

  1. Department of Biology, Washington University, St. Louis, MO, 63130, USA

    Roy Curtiss III, Sandra M. Kelly, Paul A. Gulig & Koji Nakayama

  2. Dept. of Immunology and Medical Microbiology, University of Florida College of Medicine, Box J-266 JHMHC, Gainesville, FL, 32610, USA

    Paul A. Gulig

  3. Dept. of Microbiology, School of Dentistry, Kyushu University, Higashi-ku Fukuoka 812, Japan

    Koji Nakayama

Authors
  1. Roy Curtiss III
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  2. Sandra M. Kelly
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  3. Paul A. Gulig
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  4. Koji Nakayama
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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© 1989 Springer Science+Business Media New York

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Curtiss, R., Kelly, S.M., Gulig, P.A., Nakayama, K. (1989). Stable Recombinant Avirulent Salmonella Vaccine Strains. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides V. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2046-4_4

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  • DOI: https://doi.org/10.1007/978-1-4757-2046-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2048-8

  • Online ISBN: 978-1-4757-2046-4

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