Antigenic Structure of the Fusion Glycoprotein of Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) is the major cause of lower respiratory disease in infants and young children (McIntosh and Chanock, 1985). The virus is a member of the family Paramyxoviridae, and is an enveloped single stranded RNA virus. RSV, like other paramyxoviruses, has an envelop protein called the fusion (F) protein which is responsible for fusion of the viral and cell membranes during the infectious process. Once a cell is infected, F protein in the membrane can cause the fusion of adjacent cells resulting giant cells or syncytia. Antibody to the F protein is able to block the fusion process and thereby prevent the infection of cells by virus and spread of infection between cells (Walsh and Hruska, 1983; Walsh et al., 1985).
KeywordsRespiratory Syncytial Virus Respiratory Syncytial Virus Infectian Human Respiratory Syncytial Virus Lower Respiratory Disease Pool Human Serum
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