Epitope Mimicry by Anti-Idiotype Sequences in Reverse Orientation

  • Dennis W. Metzger
  • Clayton W. Naeve
  • Victor H. Van Cleave


Antigen mimicry by anti—idiotypic internal images offers one approach to vaccine development and immune modulation. However, the rational design of internal image vaccines and an understanding of idiotypic interactions will depend upon a precise understanding of the rules which govern antigen recognition and of the structural basis for internal image expression. Previous studies using the reovirus hemagglutinin and a synthetic peptide (GAT) identified determinants in antibody internal image variable (V) regions that appeared to match continuous sequences within the respective antigens (Ollier et al., 1985 ; Bruck et al., 1986).


Backbone Atom Internal Image Antigen Mimicry Idiotypic Interaction Side Chain Placement 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Dennis W. Metzger
    • 1
    • 3
  • Clayton W. Naeve
    • 2
  • Victor H. Van Cleave
    • 1
    • 3
  1. 1.Departments of ImmunologySt. Jude Children’s HospitalMemphisUSA
  2. 2.Departments of Virology and Molecular BiologySt. Jude Children’s HospitalMemphisUSA
  3. 3.Department of Microbiology and ImmunologyUniversity of TennesseeMemphisUSA

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