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Enhancement of Primary and Secondary Immune Responses by Interferon-Gamma

  • Tilahun Yilma
  • Sally Owens
  • Elizabeth H. Fennie
  • Kevin P. Anderson

Abstract

We have investigated the effects of interferon-gamma (IFN-γ) administered with “G” glycoprotein of vesicular stomatitis virus (VSV), on the neutralizing antibody response. Treatment of mice or cattle with recombinant DNA-derived IFN-γ at the time of primary immunization with “G” glycoprotein enhanced the secondary virus-neutralizing antibody response that followed a booster administration of the same antigen without IFN-γ treatment. Enhancement was statistically significant, and occurred at relatively low doses of IFN-γ in the absence of any additional adjuvants. Cattle treated with IFN-γ at the time of primary immunization were also more resistant to VSV challenge than those immunized without IFN-γ treatment. Such treatment in conjunction with primary immunization may therefore provide a practical means of enhancing protection from viral challenge without inflammatory adjuvants or boosters.

Keywords

Antibody Response Vesicu1ar Stomatitis Virus Primary Immunization Neutralize Antibody Titer Booster Immunization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Tilahun Yilma
    • 1
    • 2
  • Sally Owens
    • 1
    • 2
  • Elizabeth H. Fennie
    • 1
    • 2
  • Kevin P. Anderson
    • 1
    • 2
  1. 1.Department of Veterinary Microbiology and ImmunologyUniversity of CaliforniaDavisUSA
  2. 2.Department of Pharmacological SciencesGenentech, Inc.South San FranciscoUSA

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