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Nephrotoxicity pp 627-632 | Cite as

Nephrotoxicity of Experimental Endotoxaemia in Rats

  • Jocemir R. Lugon
  • Mirian A. Boim
  • Oswaldo L. Ramos
  • Nestor Schor

Abstract

Endotoxaemia is frequently associated with acute renal failure (ARF) and continues to offer a very poor prognosis despite the recent progress in antibiotic therapy (1). During endotoxaemia an important release of vasoconstrictor and/or dilator hormones have been measured suggesting a that there is a hormonal role in this type of ARF (2). However, the understanding of this pathophysiology is very complex since the renal function is compromised by multifactorial effects such as pre-existing diseases (eg. diabetes, multiple myeloma, etc. ) the frequent administration of potential nephrotoxins (eg. aminoglycoside therapy) and/or prostaglandin inhibitors which all serve to complicate the assessment of renal function. Furthermore, systemic haemodynamic alterations can, per se, affect renal microcirculation.

Keywords

Filtration Ischemia Angiotensin Histamine Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Jocemir R. Lugon
    • 1
  • Mirian A. Boim
    • 1
  • Oswaldo L. Ramos
    • 1
  • Nestor Schor
    • 1
  1. 1.Nephrology DivisionEscola Paulista de MedicinaS O PauloBrazil

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