Role of Biotransformation in Acute N-(3,5-Dichlorophenyl)Succinimide-Induced Nephrotoxicity
N-(3,5-dichlorophenyl) succimide (NDPS) was developed as an agricultural fungicide during the early 1970s (Fujinami et al, 1972). Although preliminary field testing of NDPS was promising, the usefulness of NDPS as an agricultural fungicide has been limited because of potential toxicity. NDPS has been shown to produce tubular necrosis following acute exposure which is characterized by diuresis, proteinuria, glucosuria, haematuria, increased blood urea nitrogen (BUN) concentration and kidney weight, and decreased organic ion accumulation by renal cortical slices (Rankin, 1982; Rankin et al. , 1985). Chronic exposure to NDPS produces interstitial nephritis (Sugihara et al. , 1975). In addition, NDPS has been shown to promote the activity of several renal carcinogens including the nitrosamines (Ito et al, 197 4) and citrinin (Shinohara et al. , 1976).
KeywordsInterstitial Nephritis Kidney Weight Nephrotoxic Potential Blood Urea Nitrogen Concentration Renal Cortical Slice
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