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Nephrotoxicity pp 543-549 | Cite as

Nephrotoxicity and Studies on the Reabsorption and Disposal of Alpha 2U-Globulin

  • Otto W. Neuhaus

Abstract

Alpha-2u-globulin, a low-molecular weight (LMW) protein of 19,000 dalton, is synthesised by the male rat liver as a family of isoforms; pI = 4.6–5.2. This protein is an important constituent of the physiological proteinuria in adult male rats. At maturity the total urinary protein is 20–30% alpha-2u and 10% albumin. At 160 days of age the excretion of albumin and total urinary proteins are markedly increased. By one year, albumin represents nearly 60% of the total protein while alpha-2u is less than 10%. This reversal in relative content may be the consequence of a progressive glomerulonephrosis, associated with an apparent spontaneous accumulation of hyaline droplets. The nephrotic condition may be the consequence of the burden of excreting alpha-2u. Its early onset is sexdependent; female rats do not exhibit the proteinuria until a later age.

Keywords

Albumin Sodium Chloride Hydrocarbon Carboxyl Lysine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Otto W. Neuhaus
    • 1
  1. 1.Department of BiochemistryUniversity of South DakotaVermillionUSA

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