Renal Effects of Ionic and Nonionic Contrast Media: Comparison between Diatrizoate Meglumine and Iopamidol
Renal damage is a potential adverse side effect of the administration of iodinated contrast media (CM). Infact, CM represent one of the most frequent causes of renal failure (1,2). The renal damage determined by CM is sometimes irreversible (3). The mechanisms of this renal injury are not yet well understood. Hyperosmolality of the administered CM has been claimed to be an important factor of renal damage (4). No exhaustive data are available concerning the effects on renal function and nephrotoxicity of the different CM available. The aim of this study is the comparative evaluation of renal effects and nephrotoxicity of two different CM: diatrizoate meglumine (a high-osmolality ionic CM) and iopamidol (a new low-osmolality nonionic agent), after intravenous administration.
KeywordsToxicity Arthritis Filtration Urea Creatinine
Unable to display preview. Download preview PDF.
- 5.C. Bianchi, Noninvasive methods for the measurement of renal function, In: “Renal function tests. Clinical laboratory procedures and diagnosis”, C.G. Duarte, ed., p. 65, Little, Brown, Boston (1980).Google Scholar
- 18.H.J. Smith, K. Levorstad, K.J. Berg, K. Rootwelt, and K. Sveen, High dose urography in patients with renal failure. A double blind investigation of iohexol and metrizoate, Acta Radiol. Diagn. 26:213 (1985).Google Scholar
- 19.G. Cavaliere, G. Arrigo, G. D’Amico, P. Bernasconi, G. Schiavina, L. Dellafiore, and D. Vergnaghi, Tubular nephrotoxicity after intravenous urography with ionic high-osmolal and nonionic low-osmolal contrast media in patients with chronic renal insufficiency, Nephron 46:128 (1987).PubMedCrossRefGoogle Scholar
- 21.C. Donadio, G. Tramonti, P. Lorusso, R. Giordani, A. Lucchetti, A. Calderazzi, C. Sbragia, P.L. Michelassi, and C. Bianchi, Effetti renali dei mezzi di contrasto: confronto tra diatrizoato di megluminae iopamidolo (risultati preliminari), G. Ital. Nefrol. in press.Google Scholar