Nephrotoxicity of Ifosfamide in Combination Chemotherapy
Ifosfamide (Ifos) is a structural analogue of cyclophosphamide with a broad spectrum of antineoplastic activities both in solid tumours and haematological neoplasia. Its most important side effects are haemorrhagic cystitis, haematotoxicity, neurotoxicity and nephrotoxicity (1–4). Haemorrhagic cystitis and to some extent nephrotoxicity can be ameliorated by concomitant administration of 2-mercaptoethane sulphonate sodium (Mesna R).
KeywordsConcomitant Administration Antineoplastic Activity Central Nervous System Toxicity Important Side Effect Severe Proteinuria
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