Celiptium Induced Lipid Peroxidation and Toxicity in Rat Renal Cortex
The antitumour drug Celiptium (N2-methyl-9-hydroxyellipticinium) is an ellipticine derivative, effective in experimental tumours (1) and in man. Celiptium is metabolized in liver and excreted by the biliary tract (60%) and urine (30%). However, a renal metabolism occurs in both rats and humans treated with Celiptium, cysteine and N-acetylcysteine conjugates appear in the urine (2). Moreover, it was shown that isolated rat kidney cells metabolize Celiptium into the same conjugates which were found in rat or human urines whereas these compounds were not detected in bile (3).
KeywordsFatty Acid Composition Fatty Acid Methyl Ester Neutral Lipid Renal Cortex Total Phospholipid
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- 1.C. Paoletti, J.B. Le Pecq, N. Dat Xuong, P. Juret, H. Garnier, J.L. Amiel, J. Rouesse, Antitumor activity, pharmacology and toxicity of ellipticines, ellipticinium and 9-hydroxy-derivatives: preliminary clinical trials of 2-methyl-9-hydroxy-ellipticinium (NSC-264–137). Recent Results Canc. Res., 74:107 (1980)CrossRefGoogle Scholar
- 2.B. Monsarrat, M. Maftouh, G. Meunier, B. Dugue, J. Bernadou, J.P. Armand, C. Picard-Fraire, B. Meunier, C. Paoletti, Human and rat urinary metabolites of the hydroxy methylellipticinium. Identification of cysteine conjugates supporting the bioxidative alkylation hypothesis. Biochem. Pharmacol., 32:3887 (1983)PubMedCrossRefGoogle Scholar
- 4.P. Juret, A. Tanguy, A. Girard. L’ acitate d’ hydroxy-9-mithyl-2-ellipticinium. Etude toxicologique et thirapeutique chaz 100 cancereux. Nouv. Presse Med. 8:1494 (1978)Google Scholar
- 5.G. Raguinez-Viotte, C. Dadoun, P. Buchet, T. Ducastelle, J.P. Fillastre. Renal toxicity of the antitumor drug N2-methyl-9-hydroxy-ellipticinium acetate in the Wistar rat. Submitted Arch Toxicology. Google Scholar
- 6.O.B. Bayliss-High, Lipids In: Theory and practice of histological techniques, Bancroft, edited by J. D. Stevens, Melbourne-New York. p.217 (1982)Google Scholar
- 15.H. Kappus, Lipid peroxidation: mechanisms, analysis, enzymology and biological relevance. In: “Oxidative stress” edited by H. Sies, Academic Press. p. 273 (1985)Google Scholar