Abstract
During intoxications with paracetamol hepatic and renal failure may develop, the latter also in the absence of liver damage (Boyer et al., 1971; Prescott et al., 1971; Cobden et al., 1982). Several antidotes are available for the treatment of severe paracetamol poisoning, these include mainly precursors of GSH-synthesis like methionine or N-acetylcysteine (Crome et al,. 1976; Prescott et al., 1977). In animal experiments diethyldithiocarbamate (dithiocarb) was shown to be an effective antidote against paracetamol-induced hepatotoxicity, due to its strong inhibitory influence on microsomal monooxygenases (Strubelt et al., 1974; Siegers et al., 1982). No experimental or clinical data, however, are available proving the efficacy of these antidotes in preventing paracetamol-induced renal damage. Moreover, it is still unclear, whether the metabolic pathways leading to hepatotoxic intermediates of paracetamol are the same for exerting nephrotoxic response.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boyer, T.D. and Rouff, S.L. (1971). Acetaminophen-induced hepatic necrosis and renal failure. J. Am. Med. Assoc. 218, 440–441.
Brehe, J.E. and Burch, H.B. (1976). Enzymatic assay for glutathione. Anal. Biochem. 74, 189–197.
Cobden, I., Record, C.O., Ward, M.K. and Kerr, D.N.S. (1982) . Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Br. Med. J. 284, 21–22.
Crome, P., Vale, J. A. , Volans, G. N. , Widdup, B. and Goulding, R. (1976). Oral methionine in the treatment of severe paracetamol (acetaminophen) overdose. Lancet 2, 829–830.
Prescott, L.F., Wright, N., Roscoe, P. and Brown, S.S. (1971). Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdose. Lancet, 1, 519–522.
Prescott, L.F., Park, J., Ballantyne, A., Adriaenssens, P. and Proudfoot, A.T. (1977). Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 2, 432–434.
Sedlack, J. and Lindsay, R.H. (1968). Estimation of total protein-bound and non protein sulfhydryl groups in tissue with Ellman’s reagent. Anal. Biochem. 25, 192–205.
Siegers, C.-P., Larseille, J. and Younes, M. (1982). Effects of dithiocarb and (+) -catechin on microsomal enzyme activities of rat liver. Res. Commun. Chem. Pathol. Pharmacol. 36, 61–73.
Strubelt, O., Siegers, C.-P. and Schutt, A. (1974). The curative effects of cysteamine, cysteine and dithiocarb in experimental paracetamol poisoning, Arch. Toxicol. 33, 55–64.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Moller-Hartmann, W., Siegers, CP. (1989). Effects of Antidotes on the Hepato- and Nephrotoxicity of Paracetamol in the Rat. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_67
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_67
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive