Nephrotoxicity pp 383-388 | Cite as

Drug Pharmacokinetics in Renal Failure — Influence of Disease Type

  • Amor Maiza
  • Peter T. Daley-Yates


For many drugs the major route of elimination from the body is renal excretion. Therefore, a loss of renal function will lead to excessive accumulation of the drug or its metabolites in the body, unless the drug dosage is reduced. The problem is particularly acute for drugs that have a narrow therapeutic index intended for patients with severe renal insufficiency. A failure to appropriately adjust dosage can lead to toxicity, which for some drugs may be life-threatening.


Glomerular Filtration Rate Renal Clearance Narrow Therapeutic Index Severe Renal Insufficiency Papillary Necrosis 


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Amor Maiza
    • 1
  • Peter T. Daley-Yates
    • 1
  1. 1.Department of PharmacyUniversity of ManchesterManchesterUK

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