Sensitivity of in Vitro Ion Accumulation, Gluconeogenesis and other Parameters as Indicators of Cisplatin-Induced Renal Toxicity
The kidney is a complex organ which controls the fluid and salt balance, and the homeostasis of numerous other organs. Consequently, the functional integrity of the kidney is of paramount importance in maintaining health. Because of its central role in excretion, the kidney is exposed to high and often prolonged concentrations of most xenobiotics that enter the body. Adverse effects on renal function are produced by a large number of these chemicals, including heavy metals such as mercury and cadmium, and drugs such as aminoglycoside antibiotics and antineoplastic agents. One widely used antineoplastic agent whose dose limiting toxicity is to the kidney is cis-diamminedichloroplatinum-II (cisplatin, cisPt). This drug is a square planar molecule which undergoes a complex spontaneous hydrolysis to yield several uncharacterized metabolites, several of which have the potential of being the ultimate toxicant.
KeywordsToxicity Mercury Cage Platinum Cadmium
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