Advertisement

Nephrotoxicity pp 357-359 | Cite as

The Effect of Amiloride on Cisplatin Induced Nephrotoxicity and the Renal Uptake of (195mPt) Cisplatin in Male Wistar Rats

  • T. Ormond
  • S. McGuinness
  • I. Pratt
  • M. P. Ryan
  • C. A. McAuliffe
  • H. L. Sharma
  • N. D. Tinker

Abstract

Cisplatin is an effective antineoplastic agent . Its clinical use is complicated by nephrotoxicity, (Goldstein et al., 1981) hypomagnesaemia and inappropriate renal magnesium wasting (Shilsky et al., 1979) . Coadministration of diuretics decreases the general nephrotoxicity, but may exacerbate the magnesium wasting. Amiloride is a potassium and magnesium sparing diuretic (Devane and Ryan, 1983) which theoretically may overcome the cisplatin induced nephrotoxicity and magnesium loss . The purpose of this study was to evaluate the effect of amiloride on:-
  1. i)

    cisplatin induced nephrotoxicity and

     
  2. ii)

    renal, hepatic, plasma and urinary concentrations of (195mPt) cisplatin in male Wistar rats .

     

Keywords

Magnesium Urea Cage Bromide Hydrochloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baer, J.E., Jones, C.B., Spitzer, S.A. and Russo, H.F. (1967) . The potassium-sparing and natriuretic activity of N-amidino-3–5-diamino-6chloropyrazinecarboxamide hydrochloride dihydrate (amiloride hydrochloride) . J. Pharmacol . Exp. Ther. 157: 472–485.PubMedGoogle Scholar
  2. Devane, J. and Ryan, M.P. (1983) . Evidence for a magnesium-sparing action by amiloride during renal clearance studies in rats. Br. J. Pharmac.,79: 891–896.CrossRefGoogle Scholar
  3. Goldstein, R.S., Noordewier, B., Bond, J.T., Hook, J. and Mayor, G.H. (1981) . cis-Dichlorodiammineplatinum nephrotoxicity time course and dose response of renal functional impairment. Toxicol. Appl. Pharmacol., 60: 163–175.PubMedCrossRefGoogle Scholar
  4. Safirstein, R., Miller, P., and Guttenplan, J.B. (1984) . Uptake and metabolism of cisplatin by rat kidney. Kidney Int. 25:753–758.PubMedCrossRefGoogle Scholar
  5. Schilsky, R.L. and Anderson, T. (1979) . Hypomagnesemia and renal magnesium wasting in patients receiving cisplatin. Ann. Int . Med., 90: 929–931.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • T. Ormond
    • 1
  • S. McGuinness
    • 1
  • I. Pratt
    • 1
  • M. P. Ryan
    • 1
  • C. A. McAuliffe
    • 2
  • H. L. Sharma
    • 3
  • N. D. Tinker
    • 2
    • 3
  1. 1.Department of PharmacologyUniversity College DublinIreland
  2. 2.Chemistry Department, Institute of Science and TechnologyUniversity of ManchesterManchesterEngland
  3. 3.University of ManchesterManchesterEngland

Personalised recommendations