Renal Toxicity of Cis-Dichlorodiammine Platinum in Rats
Cis-Dichlorodiammine Platinum (DDP) is an effective anticancer agent that changes the natural history of many tumours, especially testicular carcinoma. However, its use in the treatment of several kinds of solid tumours has been restricted by a high renal toxicity incidence (1–3) . Acute or chronic DDP administration in experimental models have shown an important reduction on glomerular filtration rate but, the pathophysiological mechanism of this acute renal failure (ARF) is unclear.
KeywordsToxicity Catheter Filtration Platinum Inulin
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
P.P. Choie, D.S. Longnecker and A.A. Delcampo, Acute and chronic cisplatin nephropathy in rats, Lab. Invest .
44:397 (1981) .PubMedGoogle Scholar
P.J. Loehrer and L.H. Eihorn, Cisplatin, Ann. Intern. Med.
100 :704 (1984) .PubMedCrossRefGoogle Scholar
N.E. Madias and J.T. Harrington, Platinum Nephrotoxicity, Am. J. Med.
68 :307 (1978) .CrossRefGoogle Scholar
N. Schor, I. Ichikawa and B.M. Brenner, Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat, Kidney Int.
20 :442 (1981) .PubMedCrossRefGoogle Scholar
J. Fuhr, J. Kaczmarczyk and C.D. Kruettgen, Eine eunfache colorimetrische methode zur inulinbestmung for nierenclearanceuntersuchungen bei stoffwechselgesunden und diabetikern, Klin. Wochenschr
, 33 :729 (1955) .PubMedCrossRefGoogle Scholar
G.G. Vurek and S.E. Pegran, Fluorimetric method for the determination of nanogram quantities of inulin, Anal. Biochem.
16:409 (1966) .CrossRefGoogle Scholar
J.W. Viets, W.M. Deen, J.L. Troy and B.M. Brenner, Determination of serum protein concentration in nanoliter blood samples using f luorescamine or O-phthaladehyde, Anal. Biochem.
8 :513 (1978) .CrossRefGoogle Scholar
W.M. Deen, C.R. Robertson and B.M. Brenner, A model of glomerular ultrafiltration in the rat, Am. J. Phvsiol.
223: 1178 (1972) .Google Scholar
© Springer Science+Business Media New York 1989