Advertisement

Nephrotoxicity pp 291-296 | Cite as

Renal Tubular Function in Experimental and Clinical Cyclosporin (CsA) Nephrotoxicity

  • P. H. Whiting
  • D. J. Propper
  • J. G. Simpson
  • J. McKay
  • M. C. Jones
  • G. R. D. Catto

Abstract

The use of cyclosporin A (CsA) in both organ transplantation and in the treatment of autoimmune disease may ultimately be limited by the drug’s nephrotoxic properties (Klintmalm et al, 1981). Indeed a major clinical problem has been the differentiation of rejection from CsA-induced nephrotoxicity, following renal transplantation. This nephrotoxicity is characterised by impaired renal function and histologically, predominantly by tubular changes (Blair et al, 1982; Thiru et al, 1983). Although the pathogenesis of CsA-induced nephrotoxicity is still unclear, alterations in glomerulotubular function have been demonstrated (Battle et al, 1986; Gnutzman et al, 1986; Dieperink et al, 1986a, b).

Keywords

Toxicity Filtration Lithium Creatinine Cyclosporine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Battle, D. C., Gutterman, C. T Tarka, J. and Prasad, R., 1986, Effect of short-term cyclosporine A administration on urinary acidification, Clin. Nephrol., 25 (Suppl. 1): S69.Google Scholar
  2. Blair, J. T., Thomson, A. W., Whiting, P. H., Davidson, R. J. L., and Simpson, J. G., 1982, Toxicity of the immune suppressant cyclosporine A in the rat, J. Path., 135: 163.Google Scholar
  3. Carney, S. L., Wong, N. M. L., and Dirks, J. H., 1980, Effect of lithium treatment on rat renal tubule function, Nephron, 25: 293.CrossRefGoogle Scholar
  4. Dieperink, H., Kemp, E., Leyssac, P. P. and Starlint, H., 1986a, Cyclosporine A: effectiveness and toxicity in a rat model, Clin. Nephrol., 25 (Suppl. 1): S46.Google Scholar
  5. Dieperink, H., Leyssac, P. P., Kemp, E., Steinbruckl, D. and Starklint, H., 1986b: Glomerulotubular function in cyclosporine A treated rats, Clin. Nephrol., 25 (Suppl. 1): S70.Google Scholar
  6. Dieperink, H., Starklint, H. and Leyssac, P. P., 1983, Nephrotoxicity of cyclosporin — an animal model: study of the nephrotoxic effect of cyclosporine on overall renal and tubular function in conscious rats, Transplant. Proc., 15 (Suppl. 1): 2736.Google Scholar
  7. Duncan, J. I., Thomson, A. M., Simpson, J. G. and Whiting, P. H. ; 1986, Comparative toxicological study of cyclosporine and Nva2-cyclosporine in Sprague-Dawley rats, Transplantation, 42: 395.PubMedCrossRefGoogle Scholar
  8. Gerkens, J. F., Bhagwandeen, S. B., Dosen, P. J. and Smith, A. J., 1984, The effect of salt intake on cyclosporine-induced impairment of renal function in rats, Transplantation, 38: 412.PubMedCrossRefGoogle Scholar
  9. Gnutzman, K. H., Hering, K. and Gutsche, H. -U., 1986, Effect of short term cyclosporine on the diluting capacity of rat kidney, Clin. Nephrol., 25 (Suppl. 1): S51.Google Scholar
  10. Klintman, G. B. M., Iwatsuki, S. and Starzl, T. E., 1981, Nephrotoxicity of cyclosporine in liver and kidney transplant recipients, Lancet, 1: 470.CrossRefGoogle Scholar
  11. McAuley, F. T., Simpson, J. G., Thomson A. W. and Whiting, P. H., 1987a, Cyclosporin A-induced nephrotoxicity in the rat: relationship to increased plasma renin activity, Agents Actions, 21: 209.PubMedCrossRefGoogle Scholar
  12. McAuley, F. T., Whiting, P. H., Thomson, A. M. and Simpson, J. G., 1987b; The influence of enalapril or spironolactone on experimental cyclosporin nephrotoxicity, Biochem. Pharmac., 36: 699.CrossRefGoogle Scholar
  13. Thiru, S., Maher, E. R., Hamilton, D. V., Evans, D. B. and Calne, R. Y., 1983, Tubular changes in renal transplant recipients on cyclosporine, Transplant. Proc., 15 (Suppl. 1): 2846.Google Scholar
  14. Thomsen, K., 1984, Lithium clearance: a new method for determining proximal and distal tubular reabsorption of sodium and water, Nephron, 37: 217.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. H. Whiting
    • 1
  • D. J. Propper
    • 1
  • J. G. Simpson
    • 1
  • J. McKay
    • 1
  • M. C. Jones
    • 1
  • G. R. D. Catto
    • 1
  1. 1.Departments of Chemical Pathology, Pathology and MedicineUniversity of AberdeenAberdeenUK

Personalised recommendations