Renal Tubular Function in Experimental and Clinical Cyclosporin (CsA) Nephrotoxicity
The use of cyclosporin A (CsA) in both organ transplantation and in the treatment of autoimmune disease may ultimately be limited by the drug’s nephrotoxic properties (Klintmalm et al, 1981). Indeed a major clinical problem has been the differentiation of rejection from CsA-induced nephrotoxicity, following renal transplantation. This nephrotoxicity is characterised by impaired renal function and histologically, predominantly by tubular changes (Blair et al, 1982; Thiru et al, 1983). Although the pathogenesis of CsA-induced nephrotoxicity is still unclear, alterations in glomerulotubular function have been demonstrated (Battle et al, 1986; Gnutzman et al, 1986; Dieperink et al, 1986a, b).
KeywordsProximal Tubule Renal Tubular Function Lithium Clearance Renal Function Group Fractional Reabsorption
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