Nephrotoxicity pp 277-283 | Cite as

Mechanisms of Cyclosporin a Nephrotoxicity — Rat to Man

  • Hans Dieperink
  • Henrik Starklint
  • Ejvind Kemp
  • Paul Peter Leyssac


Cyclosporin A (CyA) is a cyclical undecapeptide of fungal origin (1–4), and has been used as an immunosuppressive agent in clinical medicine since 1978 (5, 6), where it has been of prime importance in the improvement of organ transplantation results. CyA’s future role in the treatment of autoimmune disease is now subject to intensive studies. However, the nephrotoxicity of the drug is a major obstacle to its successful use.


Renal Blood Flow Interstitial Fibrosis Renal Denervation Renal Vascular Resistance Renal Interstitial Fibrosis 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Hans Dieperink
    • 1
  • Henrik Starklint
    • 1
  • Ejvind Kemp
    • 1
  • Paul Peter Leyssac
    • 1
  1. 1.Laboratory of NephropathologyOdense University HospitalOdense CDenmark

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