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Nephrotoxicity pp 233-239 | Cite as

Morphological and Functional Effects in Rat Neonates of Aminoglycosides Given to the Mother During Gestation

  • J. P. Mallie
  • H. Smaoui
  • Cl. Billerey
  • M. Cheignon
  • J. Schaeverbke

Abstract

Aminoglycosides are widely used to treat gram-negative infections, which occur frequently in pregnant women and require the use of these antibiotics. The nephrotoxicity of aminoglycosides is an important consideration in the clinical use of these drugs, that has led to numerous studies (Price, 1986). However, little attention has been paid to a possible nephrotoxic effect of these antibiotics on the foetus, although they are able to cross the placental barrier.

Keywords

Toxicity Creatinine Polyethylene Glycoside Gentamicin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bakala H., Cornet S., Cheignon M., Djaziri R. and Schaeverbeke J., 1987, Basement Membrane Proteoglycans and Anionic Sites in the Fetal Rat Kidney during Late Gestation. J. Morphol. (to be published).Google Scholar
  2. Bamonte F., Al Biero L. and Ongini E., 1979, Reproductive and Teratological Studies with a New Aminoglycosides: Netilmicin (Sch-20569). Acta Pharmacol. Toxicol., 45: 145–151.CrossRefGoogle Scholar
  3. Cheignon M., Bakala H., Cornet S., Djaziri R. and Schaeverbeke J., 1987, Localization of Basement Membranes Glycoproteins in the Rat Kidney during Fetal Development. Biol. Cell., 60: (to be published).Google Scholar
  4. Gilbert Th., Leiievre-Pegorier M., Malienou R., Meulemans A. and Merlet-Benichou Cl., 1987, Effects of Prenatal and Post-natal Exposure to Gentamicin on Renal Differentiation in the Rat. Toxicology, 43:301–313.PubMedCrossRefGoogle Scholar
  5. Houghton D.C., Hartnett M., Campbell-Boswell M., Porter G. and Bennett W.M., 1976, A light and Electron Microscopic Analysis of Gentamicin Nephrotoxicity in Rats. Am. J. Pathol., 82:589–612.PubMedGoogle Scholar
  6. Kavlock R.J. and Gray J.A., 1982, Evaluation of Renal Function in Neonatal Rats. Biol. Neonate, 41:279–288.PubMedCrossRefGoogle Scholar
  7. Kavlock R.J. and Gray J.A., 1983, Morphometric, Biochemical and Physiopathological Assessment of Perinatally Induced Renal Dysfunction. J. Toxicol. Envir. Health, 11:1–3.CrossRefGoogle Scholar
  8. Mallie, J.P., Gerard H. and Gerard A., 1984, Gentamicin Administration to Pregnant Rats: Effect on Fetal Renal Development in utero. Dev. Pharmacol. Ther., 7:89–92.PubMedGoogle Scholar
  9. Mallie, J.P., Gerard H. and Gerard A., 1985, Developing kidney and inutero exposure to gentamicin, in: “Renal Heterogeneity and Target Cell Toxicity, P.H. Bach and E.A. Lock eds., John Wiley & Sons, Chichester, pp 365–368.Google Scholar
  10. Mallie, J.P., Gerard H. and Gerard A., 1986, In-utero Gentamicin-lnduced Nephrotoxicity in Rats. Fediatr. Pharmacol., 5:229–239.Google Scholar
  11. Mallie, J.P., Coulon G., Billerey Cl. and Faucourt A., 1987, In-utero Induced Aminoglycosides Nephrotoxicity in Rat Neonates. Kidney International (accepted).Google Scholar
  12. Price K.E., 1986, Aminoglycosides Research 1975–1985. Prospects for Development of Improved Agents. Antimicrob. Ag. Chemother., 29:543–548.CrossRefGoogle Scholar
  13. Provoost A.P., Adejuyigbe O. and Wolff E.D., 1985, Nephrotoxicity of Aminoglycosides in Young and Adult Rats. Pediatr. Res., 19: 1191–1196.PubMedCrossRefGoogle Scholar
  14. Solez K., Racusen L.C. and Olsen S., 1983, The Pathology of Drug Nephrotoxicity. J. Clin. Pharmacol., 23:484–490.PubMedCrossRefGoogle Scholar
  15. Stolte H. and Alt J.M., 1982, The choice of animals for nephrotoxic investigations, In: “Nephrotoxicity, Assessment and Pathogenesis”, P.H. Bach et al., eds., John Wiley & Sons, Chichester, pp 102–112.Google Scholar
  16. Weinberg E.H., Fleld W.E., Gray W.D., Klein M.F., Robbins G.R. and Schwartz E., 1981, Preclinical Toxicologic Studies of Netilmicin. Arzneim Forsch. Drug Res., 31: 816–822.Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. P. Mallie
    • 1
  • H. Smaoui
    • 2
  • Cl. Billerey
    • 3
  • M. Cheignon
    • 2
  • J. Schaeverbke
    • 2
  1. 1.Lab. de NephrologieUniversite NancyVandoeuvre CedexFrance
  2. 2.Lab. de Biologie CellulaireUniversite Paris 7Paris Cedex 05France
  3. 3.Lab. d’Anatomie PathologiqueBesancon CedexFrance

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