Nephrotoxicity pp 207-216 | Cite as

Possible Role of the Renin-Angiotensin System in the Development of Gentamicin Nephrotoxicity in the Rat

  • J. P. Morin
  • N. Thomas
  • H. Toutain
  • H. Borghi
  • J. P. Fillastre


The possible involvement of the renin angiotensin system in the development of drug induced renal failure was investigated by inhibiting the activity of Angiotensin Converting Enzyme (ACE) with Perindopril, a new specific and potent inhibitor of ACE (1). The anti-hypertensive activity of Perindopril is similar to that of Ramipril and greater than that of Enalapril (2). The pattern of gentamicin induced kidney damage is now well established (3,4) and thus allowed the use this drug to produce a model of drug induced renal failure with proximal tubule injury. This study was performed in Wistar rats and consisted of the evaluation of renal morphological, biochemical and functional parameters.


Angiotensin Convert Enzyme Renal Cortex Renin Angiotensin System Proximal Tubule Cell Versus Versus Versus Versus Versus 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. P. Morin
    • 1
  • N. Thomas
    • 1
  • H. Toutain
    • 1
  • H. Borghi
    • 1
  • J. P. Fillastre
    • 1
  1. 1.Inserm U-295Universite de RouenSaint Etienne Du RouvrayFrance

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