Gentamicin (GM) nephrotoxicity is most evident in the proximal tubules which sustain injury as a result of membrane-related events (1–3). Silymarin (SL), an extract from the plant milk thistle, has been shown to exert membrane protective effects (4). The possibility that silymarin may prevent or ameliorate GM-induced nephrotoxicity is investigated in a rat model.
KeywordsUrinary Protein Excretion Serum Creatinine Concentration Gentamicin Administration Gentamicin Nephrotoxicity 223c 223c 220c 292a
Unable to display preview. Download preview PDF.
- 4.G. Ramellini, J. Meldolesi, Stablization of isolated rat liver plasma membranes by treatment in vitro with silymarin, Arzneim-Forsch (Drug Res) 24:544–552 (1977).Google Scholar
- 9.E. Magliulo, P.G. Carosi, L. Minoli, S. Gorini, Studies on the regenerative capacity of the liver in rats subjected to partial hepatectomy and treated with silymarin, Arzneim-Forsch (Drug Res) 23:161–167 (1973) .Google Scholar