Nephrotoxicity pp 147-170 | Cite as

Drug Induced Renal Effects of Cyclosporine, Aminoglycoside Antibiotics and Lithium: Extrapolation of Animal Data to Man

  • George A. Porter
  • William M. Bennett


Drugs may have either a beneficial or adverse effect on renal function. It is the latter effect we wish to focus on since 10% nephrological consultations involve the possibility of drug-induced renal injury (Porter and Bennett, 1985). Thus information regarding prevalence, clinical presentation, pathophysiological mechanisms of injury and methods of modifying it have become a significant area of research. Most studies are designed to assess the potential risk which a drug possesses for inducing significant nephrotoxicity in a given patient. Since toxicology studies the adverse effects of chemicals on living organisms and assesses the probability of their occurrence, the two expected outcomes of a toxicological analysis are risk assessment and risk prediction. However, clinical toxicology combines the science of toxicology with the art of medicine; thus, the contribution of each is critical in the study of druginduced nephrotoxicity. Scientifically, both the quantitative and qualitative in vivo and in vitro effect of drugs in the kidney are important contributors to the final assessment. However, the answer most often sought i.e., to predict occurrence in man, must occur in the face of limited scientific data as it involves the extrapolation of one set of exposure conditions to another circumstance involving different species.


Toxicity Creatinine Angiotensin Prostaglandin Cyclosporine 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • George A. Porter
    • 1
  • William M. Bennett
    • 1
  1. 1.Department of MedicineOregon Health Sciences University PortlandUSA

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