Low Molecular Weight Proteins in the Kidney of Copper-Loaded Rats
A high proportion of renal Cu has been identified (Bremner et al., 1977) bound to the LMWP metallothionein in Cu-loaded rats, and to a lesser extent, in Cu-poisoned sheep. Moreover, Cu-MT administered parenterally to rats was found to be excreted efficiently and preferentially by the kidneys, and during dietary supplementation urinary metallothionein (MT) concentrations increased substantially in Cu-loaded rats (Bremner et al. 1978; 1986) .
KeywordsZinc Formalin Filtration Polypeptide Paraffin
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