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Nephrotoxicity pp 755-760 | Cite as

Micropuncture Studies on Mechanisms of Proteinuria in Early Adriamycin-Nephrosis in MWF-RATS

  • Uwe Haberstroh
  • Mechthild Soose
  • Gloria Rovira-Halbach
  • Reinhard Brunkhorst
  • Hilmar Stolte

Abstract

The sensitivity of the kidney to many compounds is well recognized, and sequences of pathological events have been documented in detail. A model compound to induce nephrotic syndrome in rodents is adriamycin, an anthracyclin antitumour drug widely used in chemotherapy. As described by Bertani et al. (1982), pathological changes such as proteinuria, hyper-coagulability, and hyperlipemia occur with adriamycin use.

Keywords

Permeability Toxicity Filtration Albumin Cage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alt, J.M., Krisch, K., and Hirsch, K., 1975, Isolation of an inducible amidase from Pseudomonas acidovorans AE1, J. Gen. Microbiol., 87:260.PubMedGoogle Scholar
  2. Alt, J.M., von der Heyde, D., Assel, E., and Stolte, H., 1981, Characteristics of protein excretion in glomerular and tubular disease, Contr. Nephrol., 24:115.Google Scholar
  3. Bachur, N., Gordon, G.L., and Gee, M.V., 1977, Anthracyclin antibody augmentation of microsomal electron transport and free radical formation, Mol. Pharmacol., 13:901.PubMedGoogle Scholar
  4. Baldamus, C.A., Galaske, R., Eisenbach, G.M., Krause, H.P., and Stolte, H., 1975, Glomerular protein filtration in normal and nephritic rats. A micropuncture study, Contr. Nephrol., 1:37.Google Scholar
  5. Bakker, W.W., Kalicharan, D., Donga, J., Hulstaert, C.E., and Hardonk, M.J., 1987, Decreased ATPase activity in adriamycin nephrosis is independent of proteinuria, Kidney Int., 31:704.PubMedCrossRefGoogle Scholar
  6. Bertani, T., Poggi, A., Pozzoni, R., Delaini, F., Sacchi, G., Thoua, Y., Mecca, G., Remuzzi, G., and Donati, M.B., 1982, Adriamycin-induced nephrotic syndrome in rats. Sequence of pathological events, Lab. Invest., 46:16.PubMedGoogle Scholar
  7. Calandra, S., Traugi, P., Ghisellini, M., Gherardi, L.E., 1983, Plasma and urine lipoproteins during development of nephrotic syndrome induced in the rat by adriamycin, Exper. Molec. Path., 39:282.CrossRefGoogle Scholar
  8. Fajardo, L.F., Eltringham, J.R., Stewart, J.R., and Klauber, M.R., Adriamycin nephrotoxicity, Lab. Invest., 43:242.Google Scholar
  9. Hackbarth, H., Gartner, K., Alt, J., and Stolte, H., 1980, A subline of the Munich Wistar (MW) strain, response to selection for surface glomeruli, Rat News Lett., 7:23.Google Scholar
  10. Mimnaugh, E.G., Trush, M.A., and Gram, T.E., 1986, A possible role for membrane lipid peroxidation in anthracyclin nephrotoxicity, Biochem. Pharmac., 35:4327.CrossRefGoogle Scholar
  11. O’Donnell, M.P., Michels, L., Kasiske, B., Raij, L., and Keane, W. F., 1985, Adriamycin-induced chronic proteinuria: a structural and functional study, J. Lab. Clin. Med., 106:62.PubMedGoogle Scholar
  12. Rovira-Halbach, G., Alt, J.M., Brtnkhorst, R., Frei, U., Kuhn, K., and Stolte, H., 1986, Single nephron hyperfiltration and proteinuria in a newly selected rat strain with superficial glomeruli, Renal Physiol., 9:317.PubMedGoogle Scholar
  13. Scheulen, M.E., Hoensch, H., Kappus, H., Seeber, S., and Schmidt, C.G., 1987, Positive correlation between decreased cellular uptake, NADPH-glutathione reductase activity and adriamycin resistance in Ehrlich ascites tumor lines, Arch. Toxicol., 60:154.PubMedCrossRefGoogle Scholar
  14. Van Vleet, J.F., and Ferrans, V.J., 1980, Clinical and pathologic features of chronic adriamycin toxicosis in rabbits, Am. J. Vet. Res., 41:1462.PubMedGoogle Scholar
  15. Weening, J.J., and Rennke, H.G., 1983, Glomerular permeability and polyanion in adriamycin nephrosis in the rat, Kidney Int., 24:152.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Uwe Haberstroh
    • 1
  • Mechthild Soose
    • 1
  • Gloria Rovira-Halbach
    • 1
  • Reinhard Brunkhorst
    • 1
  • Hilmar Stolte
    • 1
  1. 1.Division of NephrologyHannover Medical SchoolHannoverGermany

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