Nephrotoxicity pp 699-704 | Cite as

Immunocytochemical Localization of Glutathione Peroxidase in Uremic Rat Kidney

  • S. Mizuiri
  • K. Hirata
  • S. Izumi
  • N. Komatsu
  • S. Yoshimura
  • K. Watanabe
Chapter

Abstract

Lipid peroxidation is the oxidative deterioration of polyunsaturated lipid (1). Glutathione peroxidase (GSH-Po) is the enzlme which catalyzes the reduction of lipid peroxides with the concomitant oxidation of glutathione (2). Previously we reproted that the immunohistochemical localization of GSH-Po was mainly in the proximal tubules, there the proximal portions (S1+S2) were more intensely stained than the distal portion (S3), and the immunocytochemical localization of GSH-Po swas in cytosol, including the core of microvilli and lysosomes of the epithelial cells in proximai tubules (PT) in normal rat kidney (3). This study was designed to investigate the immunocytochemical localization of GSH-Po in the uremic rat kidney in order to clarify the pathophysiological significance of the enzyme.

Keywords

Filtration Albumin Mercury Creatinine Glutathione 

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • S. Mizuiri
    • 1
  • K. Hirata
    • 1
  • S. Izumi
    • 2
  • N. Komatsu
    • 2
  • S. Yoshimura
    • 2
  • K. Watanabe
    • 3
  1. 1.Dept. of NephrologyToho University School of MedicineTokyoJapan
  2. 2.Cell. Biology Research LaboratoryTokai UniversityIsehara City, KanagawaJapan
  3. 3.Department of PathologyTokai UniversityIsehara City, KanagawaJapan

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