Nephrotoxicity pp 681-684 | Cite as

Investigations on the Nephrotoxic Potential Of Recombinant Human Tumour Necrosis Factor

  • Ulrike Metz-Kurschel
  • Erhard Kurschel
  • Norbert Niederle

Abstract

Tumour necrosis factor (TNF) is a protein produced by macrophages and monocytes after induction with endotoxin. It has the same primary structure as cachectin which is an important mediator of toxic shock and both substances are probably identical.

Keywords

Hydration Filtration Lactate Creatinine Electrophoresis 

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References

  1. 1.
    B. Beutler, A. Cerami, Cachectin: More than a tumor necrosis factor, N Enal J Med. 316:379–384 (1987).CrossRefGoogle Scholar
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    R. Munker, H.Ph. Koeffler, Tumor necrosis factor, Recent Adv Klin Wochenschr. 65:345–352 (1987)CrossRefGoogle Scholar
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    D. Maruhn, I. Fuchs, G. Mues, K.D. Bock, Normal limits of urinary excretion of eleven enzymes, Clin Chem. 22:1567–1574 (1976)PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Ulrike Metz-Kurschel
    • 1
  • Erhard Kurschel
    • 2
  • Norbert Niederle
    • 2
  1. 1.Department of Renal and Hypertensive DiseasesUniversity Medical SchoolEssenGermany
  2. 2.West German Tumour CentreUniversity Medical SchoolEssenGermany

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