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Tubulin as a G Protein?

  • Mark M. Rasenick
  • Yan Kun
  • Nan Wang

Abstract

GTP binding proteins in the synaptic membrane appear to mediate several receptor induced processes. These processes and the G-proteins mediating them include the stimulation [Gs] and inhibition [Gi] of adenylate cyclase, the gating of K+ [Gi] and Ca++ channels and the activation of phospholipase c [G?]. Several other processes might be G protein mediated as well, but the identity of the specific G proteins involved has not been determined. For many of these G proteins, the amino acid sequence and the nature of gene coding for that protein have been established. Furthermore, the tertiary structure of some is known or surmised and specific molecular domains have been suggested to participate in various aspects of G protein function.

Keywords

Adenylate Cyclase Microtubule Assembly Synaptic Membrane Tubulin Dimer Adenylate Cyclase System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Mark M. Rasenick
    • 1
  • Yan Kun
    • 1
  • Nan Wang
    • 1
  1. 1.Dept. of Physiology and Biophysics and the Committee on Neuroscience Univ. of Illinois College of MedicineChicagoUSA

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