New Structural Data on Elongation Factor-Tu:Gdp Based on X-Ray Crystallography
The GDP binding proteins (G-proteins) have attracted much attention in recent years for many good reasons. One good reason is that some of these represent a biomolecular switching mechanism with a possibility of amplification of extracellular signals. Most (if not all) have a specific GDP- binding domain of about 200 residues. This domain can be in an “on-state” complexed with GTP. This state is transformed to the “off-state” by hydrolysis of GTP to GDP. The G-proteins in their “on-state” influence the reactions of other proteins to amplify the signal.
KeywordsSecondary Structure Element Phosphoryl Group Ternary Complex Formation Guanosine Diphosphate Topology Diagram
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