Advertisement

Molecular and Developmental Biology Aspects of Fibroblast Growth Factor

  • Denis Gospodarowicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)

Abstract

Basic and acidic fibroblast growth factors (FGFs) are two closely related peptides of Mr =16000 that act as potent mitogens and differentiation factors or a wide variety of mesoderm and neuroectoderm derived cells. Basic FGF (bFGF pI 9.6) was first identified by its ability to cause the proliferation and phenotypic transformation of BALB-C 3T3 fibroblasts (Gospodarowicz,1974;Gospodarowicz and Moran,1974), while acidic FGF (aFGF, pI 5.6) was first identified by its ability to cause the proliferation and delayed differentiation of myoblasts (Gospodarowicz et al.,1975). It was later rediscovered on the basis of its ability to stimulate endothelial cell proliferation (Lemmon et al.,1982; Maciag et al.,1978).

Keywords

Fibroblast Growth Factor Granulosa Cell Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Endothelial Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abraham, J.A., Whang, J.L., Tumolo A., Mergia, A., and Fiddes, J.C., 1987, Human basic fibroblast growth factor: nucleotide sequence genomic organization and expression in mammalian cells, in: Molecular Biology of Homo Sapiens, Cold Spring Harbor, New York, Vol. 51, pp. 657–668.Google Scholar
  2. Abraham, J.A., Whang, J.L., Tumolo, A., Mergia, A., Friedman, J., Gospodarowicz, D., and Fiddes, J.C., 1986a, Human basic fibroblast growth factor: nucleotide sequence and genomic organization, EMBO (Europ. Molec. Biol. Org.) J., 5: 2523–2528.Google Scholar
  3. Abraham, J.A., Mergia, A. Whang, J.L., Tuomolo, A., Friedman, J., Hjerrild, K.A., Gospodarowicz,D., and Fiddes,J.C., 1986b, Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor, Science, Washington D.C., 233: 545–548.Google Scholar
  4. Baird, A., Durkin, T., 1986, Inhibition of endothelial cell proliferation by type B transforming growth factor: interactions with acidic and basic fibroblast factors, Biochem. Biophys. Res. Commun., 138: 476–482.Google Scholar
  5. Baird, A., Esch, F., Mormede, P., Ueno, N., Ling, N., B8hlen, P., Ying, S.Y., Wehrenberg, W.B., and Guillemin,R., 1986, Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues, Recent Prog. in Hormone Research, 42: 143–205.Google Scholar
  6. Dickson, C., and Peters, G., 1987, Potential oncogene product related to growth factors, Nature, 326: 833.PubMedCrossRefGoogle Scholar
  7. Dickson, C., Smith, R., Brookes, S., and Peters, G., 1984, Tumorogenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region Int-2, Cell, 37: 529–536.PubMedCrossRefGoogle Scholar
  8. Esch, F., Ueno, N., Baird, A., Hill, F., Denoroy, L., Ling, N.Google Scholar
  9. Gospodarowicz, D., and Guillemin,R., 1986, Primary structure of bovine brain acidic fibroblast growth factor (FGF), Biochem. Biophys. Res. Commun., 133: 554–562.Google Scholar
  10. Ferrara, N., Schweigerer, L., Neufeld, G., and Gospodarowicz, D. A new function for pituitary follicular cells: The production of basic Fibroblast groth factor, Proc. Natl. Acad. Sci., USA.In press.Google Scholar
  11. Frater-Schroder, M., Muller, G., Burchmeier, W., and B8hlen, P., 1986, Transforming growth factor B inhibits endothelial cell proliferation, Biochem. Biophys. Res. Commun., 137: 295–302.Google Scholar
  12. Gimenez-Gallego, G., Conn, G., Hatcher, V.B., and Thomas,K.A., 1986, Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities, Biochem. Biophys. Res. Commun., 135: 561–566.Google Scholar
  13. Gospodarowicz, D., 1974, Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth, Nature, London 249: 123–127.Google Scholar
  14. Gospodarowicz, D., 1979, Fibroblast and epidermal growth factors: their uses in vivo and in vitro in studies on cell functions and cell transplantation, Mol. Cell. Biochem., 25: 79–110.Google Scholar
  15. Gospodarowicz, D., 1983, The control of mammalian cell proliferation by growth factors, extracellular matrix and lipoproteins, J. Inv. Derm., 81: 41–50.Google Scholar
  16. Gospodarowicz, D., 1985, Biological activity in vivo and in vitro of pituitary and brain fibroblast growth factor, in: “Mediators in Cell Growth and Differentiation,” R.J. Ford, A.L. Maizel,eds, Raven Press, New York, pp. 109–134.Google Scholar
  17. Gospodarowicz, D., 1987, Purification of brain and pituitary FGF, in: “Methods in Enzymology: Peptide growth factors,” D.Barnes and D. Sirbasku, eds., Academic Press, Orlando, FL, 147A: 106–119.CrossRefGoogle Scholar
  18. Gospodarowicz, D., and Cheng, J., 1986, Heparin protects basic and acidic FGF from inactivation, J. Cell. Physiol., 128: 475–484.Google Scholar
  19. Gospodarowicz, D., and Greenburg, G., 1981, Growth control of mammalian cells. Growth factors and extracellular matrix, in:“The Biology of Normal Human Growth,” M. Ritzen, A. Aperia, K. Hall, A. Larsson, A. Zetterberg, R. Zetterstrom, eds., Raven Press, New York, pp. 121.Google Scholar
  20. Gospodarowicz, D., and Mescher, A.L., 1981, Fibroblast growth factor and vertebrate regeneration, in: “Advances in Neurology: Neurofibromatosis,” V.M.Riccardi, and J.J.Mulvihill, eds., Raven Press,New York, Vol. 29, pp. 149–171.Google Scholar
  21. Gospodarowicz, D.,and Moran, J., 1974, Effect of a fibroblast growth factor, insulin, dexamethasone, and serum on the morphology of BALB/c 3T3 cells, Proc.Natl.Acad.Sci. USA, 71: 4648–4652.Google Scholar
  22. Gospodarowicz, D., and Tauber, J.-P., 1980, Growth factors and extracellular matrix, Endocrine Review, 1: 201–227.CrossRefGoogle Scholar
  23. Gospodarowicz, D., Cohen, D.C., and Fujii, D.K., 1982, Regulation of cell growth by the basal lamina and plasma factors: relevance to embryonic control of cell proliferation, in:“Cold Spring Harbor Conferences on Cell Proliferation Vol. 9: Growth of cells in hormonally deficient media,” G.Sato, A.Pardee, and D.Sirbasku, eds., Cold Spring Harbor, New York, pp. 95–124.Google Scholar
  24. Gospodarowicz, D., Greenburg, G., and Bialecki, H., 1978, Factors involved in the modulation of cell proliferation in vivo and in vitro: the role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells, In Vitro, 14: 85–118.Google Scholar
  25. Gospodarowicz, D., Neufeld, G., and Schweigerer, L., 1986a, Fibroblast growth factor, Mol.Cell.Endocrin., 46: 187–206.CrossRefGoogle Scholar
  26. Gospodarowicz, D., Neufeld, G., and Schweigerer, L., 1986b, Molecular and biological characterization of fibroblast growth factor: an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm-derived cells, Cell. Differ., 19: 1–17.Google Scholar
  27. Gospodarowicz, D., Weseman, J., and Moran, J., 1975, Presence in the brain of a mitogenic agent distinct from fibroblast growth factor that promotes the proliferation of myoblasts in low density culture, Nature, London, 256: 216–220.Google Scholar
  28. Gospodarowicz, D., Ferrara, N., Schweigerer, L., and Neufeld, G.,1987, Structural characterization and biological functions of fibroblast growth factor, Endocrine Review, 8: 1–20.Google Scholar
  29. Gospodarowicz, D., Weseman, J., Moran, J., and Lindstrom, J.,1976, Effect of fibroblast growth factor on the division and fusion of bovine myoblasts,J.Cell Biol., 70: 395–405.Google Scholar
  30. Gospodarowicz, D., Cheng, J., Lui, G.M., Baird, A., Esch, F., and B8hlen, P., 1985, Corpus luteum angiogenic factor is related to fibroblast growth factor, Endocrinology, 117: 2283–2291.CrossRefGoogle Scholar
  31. Gospodarowicz, D., Vlodaysky, I., Greenberg, G., Alvarado. J., Johnson, L.K., and Moran, J., 1979, Cellular shape is determined by the extracellular matrix and is responsible for the control of cellular growth and function, in: “Cold Spring Harbor Conferences on Cell Proliferation, Vol 6: Hormones and Cell Culture,”Google Scholar
  32. R.Ross, G. Saro, eds., Cold Spring Harbor, New York, pp.561–592.Google Scholar
  33. Hauschka, P.V., Mavrakas, A.E., Iafrati, M.D., Doleman, S.E.,and Klagsbrun, N., 1986, Growth factors in bone matrix: isolation of multiple types by affinity chromatography on heparin-Sepharose, J.Biol.Chem., 261: 12665–12674.Google Scholar
  34. Jaye, M., Howk, R., Burgess, W., Ricca, G.A., Chiu, I.M., Ravera, M.W., O’Brien, S.J., Modi, W.S., Maciag, T., and Drohan, W.N., 1986, Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization, Science, 233: 541–544.PubMedCrossRefGoogle Scholar
  35. Jakobovits, A., Shackleford, G.M., Varmus, H.E., and Martin, G.R., 1986, Two proto-oncogenes implicated in mammary carcinogenesis, Int-1 and Int-2, are independently regulated during mouse development, Proc.Natl.Acad.Sci.,USA, 83: 7806–7810.PubMedCrossRefGoogle Scholar
  36. Klagsbrun, M., Sasse, J., Sullivan, R., and Smith, J.A., 1986, Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor, Proc.Natl.Acad.Sci., USA, 83: 2448–2452.Google Scholar
  37. Lathrop, B., Olson, E., Glaser, L., 1985, Control of myogenic differentiation by fibroblast growth factor is mediated by position in the G1 phase of the cell cycle, J. Cell Biol., 101: 2194–2208.PubMedCrossRefGoogle Scholar
  38. Lemmon, S.K., Rielly, M.C., Thomas, K.A., Hoover, G.A., Maciag, T.,and Bradshaw, R., 1982, Bovine fibroblast growth factor: comparison of brain and pituitary preparations, J. Cell. Biol., 95: 162–169.Google Scholar
  39. Maciag, R., Cerundolo, J., Isley, S., Kelley, P.R., and Forand, R., 1979, An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization, Proc.Natl.Acad.Sci.,USA, 76: 5674–5678.PubMedCrossRefGoogle Scholar
  40. Mergia, A., Tumolo, A., Haaparanta, T., Whang, J.L., Gospodarowicz, D., Abraham, J.A., and Fiddes, J.C., 1987, Isolation and characterization of the human gene for acidic FGF, In preparation.Google Scholar
  41. Montesano, R., Vassali, J.D., Baird, A., Guillemin, R., and Orci, L., 1986, Basic fibroblast growth factor induces angiogenesis in vitro, Proc. Natl.Acad.Sci.,USA, 83: 7297–7301.Google Scholar
  42. Neufeld, G., and Gospodarowicz, D., 1986, Basic and acidic fibroblast growth factor interact with the same cell surface receptor, J.Biol.Chem., 261: 5631–5637.PubMedGoogle Scholar
  43. Neufeld, G., and Gospodarowicz, D., Protamine Sulfate Inhibits the mitogenic activities of the extracellular matrix and FGF, but potentiates that of epidermal growth factor, J. Cell Physiol. In press.Google Scholar
  44. Nieuwkoop, P., 1969, The formation of mesoderm in Urodelean amphibians. I.Induction by the endoderm, Wilhelm Roux’ Arch. Entw. Mech. Org., 162: 341–373.Google Scholar
  45. Nilsen-Hamilton, M., and Hamilton, R.T., 1987, Detection of proteins induced by growth regulators, Methods in Enzymology, 147:427–444, Academic Press, Orlando, Florida.Google Scholar
  46. Nilsen-Hamilton, M., Hamilton, R.T., and Alvarez-Azaustre, E., 1986, A relationship between mitogen regulated protein ( MRP) and proliferin, a member of the prolactin/growth hormone family, Gene, 51: 163–170.Google Scholar
  47. Pettman, B., Labourdette, G., Weibel, M., and Sensenbrenner, M., 1986, The brain fibroblast growth factor (FGF) is localized in neurons, Neurosci. Letters, 68: 175–179.Google Scholar
  48. Risau, W., 1986, Developing brain produces an angiogenesis factor, Proc.Natl.Acad.Sci.,USA, 83: 3855–3859.PubMedCrossRefGoogle Scholar
  49. Schweigerer, L., Neufeld, G., Friedman, J., Abraham, J.A., Fiddes, J.C., and Gospodarowicz, D., 1987a, Capillary endothelial cells express basic fibroblast growth factor, a mitogen that stimulates their own growth, Nature, London, 325: 257–259.Google Scholar
  50. Schweigerer, L., Neufeld, G., Mergia, A., Abraham, J.A., Fiddes, J.C., and Gospodarowicz, D., 1987b, Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors, Proc.Natl.Acad.Sci., USA, 84: 842–846Google Scholar
  51. Slack, J.M., 1983, “From egg to embryo: determinative events in early development,” Cambridge University Press, Cambridge and London.Google Scholar
  52. Slack, J.M., Darlington, B., Heath, H., and Godsave, S., 1987, Heparin binding growth factors as agents of mesoderm induction in early Xenopus embryo, Nature, 326: 197–200.PubMedCrossRefGoogle Scholar
  53. Sporn, M.B., and Roberts, A.B., 1985, Autocrine growth factor and cancer, Nature, 313: 745–747.PubMedCrossRefGoogle Scholar
  54. Ueno, K., Baird, A., Esch, F., Ling, N., and Guillemin, R., 1986, Isolation of an amino acid terminal extended form of basic fibroblast growth factor, Biochem. Biophys. Res. Commun., 138: 580–588.Google Scholar
  55. Vlodaysky, I., Folkman, J. Sullivan, R., Frieman, R., Ishai, R., Michaeli, Sasse, J., and Klagsbrun, M., 1987, Endothelial cells derive basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix, Proc. Natl. Acad. Sci., USA, 84: 2282–2296.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Denis Gospodarowicz
    • 1
  1. 1.Cancer Research InstituteUniversity of California Medical CenterSan FranciscoUSA

Personalised recommendations