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The Endosomal Apparatus and Transmembrane Signalling

  • J. J. M. Bergeron
  • W. H. Lai
  • D. G. Kay
  • J. J. DohertyII
  • M. N. Khan
  • B. I. Posner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)

Abstract

The binding of insulin, prolactin, and epidermal growth factor to their respective receptors on liver parenchymal cells rapidly leads to their internalization along with their associated receptors. As reviewed elsewhere, 1–5 high concentrations of these ligand-receptor complexes accumulate initially in a heterogeneous group of compartments collectively termed the endosomal apparatus. Conceptually, the endosomal apparatus bridges the plasmalemma with secondary lysosomes and involves at least indirectly the Golgi apparatus (Fig. 1 and 14–17). In liver, components of the endosomal apparatus have been visualized and identified by electron microscope radioautography, 18 EM immunocytochemistry, 19–23 and subcellular fractionation 7–11,24. These techniques have demonstrated that the endosomal components are not lysosomes, 10,12,18,25 that a sequential transport of ligands and receptors among endosomal components can be observed, 8,9,26,29 and that morphologically different microdomains can be observed in continuous structures segregating ligands (vesicular) from receptors (tubular)19–21.

Keywords

Epidermal Growth Factor Receptor Epidermal Growth Factor Insulin Receptor Transmembrane Signalling Epidermal Growth Factor Receptor Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • J. J. M. Bergeron
    • 1
  • W. H. Lai
    • 1
  • D. G. Kay
    • 1
  • J. J. DohertyII
    • 1
  • M. N. Khan
    • 1
  • B. I. Posner
    • 1
  1. 1.McGill UniversityMontrealCanada

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