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The Ca2+/Phospholipid-Binding Proteins of the Submembraneous Skeleton

  • Chapter
Biology of Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 234))

Abstract

Among the best characterized substrates for the protein-tyrosine kinases are two proteins with molecular weights between 34 and 39 kDa and pI’s about 7. These proteins have been given a variety of names (Table 1), but I will refer to them here as p36 and p35. It has recently emerged that p36 and p35 are structurally and functionally related to each other and to at least two additional proteins, p67 and p33. All four proteins contain multiple copies of a related 75 amino acid repeat, and all of them bind to phospholipid bilayers in the presence of µM concentrations of Ca2+ and are localized to the inner face of cytoplasmic membranes. The true functions of these proteins are not known, but there are two major schools of thought. The first proposes that these proteins have structural roles in the cortical submembrane skeleton of the cell. The second holds that these proteins act as inhibitors of phospholipase A2, and have called them lipocortins. Here I will review the properties of these proteins, and discuss the evidence for their possible functions.

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Authors and Affiliations

  1. Molecular Biology and Virology Laboratory, The Salk Institute, P.O Box 85800, San Diego, California, 92138, USA

    Tony Hunter

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  1. Tony Hunter
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Editors and Affiliations

  1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Ontario, Canada

    Jeffrey E. Kudlow

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    David H. MacLennan

  3. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada

    Alan Bernstein

  4. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Ontario, Canada

    Avrum I. Gotlieb

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© 1988 Springer Science+Business Media New York

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Hunter, T. (1988). The Ca2+/Phospholipid-Binding Proteins of the Submembraneous Skeleton. In: Kudlow, J.E., MacLennan, D.H., Bernstein, A., Gotlieb, A.I. (eds) Biology of Growth Factors. Advances in Experimental Medicine and Biology, vol 234. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1980-2_12

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  • DOI: https://doi.org/10.1007/978-1-4757-1980-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1982-6

  • Online ISBN: 978-1-4757-1980-2

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