Broad Beam Ultrasound for Acceleration of Struvite Calculi Dissolution Using Citric Acid-Based Chemolytic Agents

  • George E. Geier
  • Daniel M. Newman
  • Francis J. Fry
  • Steven L. Griffith
  • Thomas D. Franklin


A computer-controlled, broad-beam ultrasound system is presented which accelerates struvite stone chemolysis in vitro. Hemiacidrin chemolysis was greatly potentiated and was linearly dependent on stone surface area and total ultrasound time. Dissolution also was dependent on citric acid concentration and solution pH with only minimal dissolution above pH 4.2. Citrate concentrations of 12% provided maximal dissolution which was further potentiated by 0.1 molar ethylene diaminatetraacetic acid (EDTA). With or without ultrasound application, the citrate-based compound demonstrated an eightfold activity over hemiacidrin. Magnesium was found to competitively inhibit dissolution activity.


Dissolution Rate Shock Wave Lithotripsy Stone Size Urinary Calculus Citrate Concentration 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • George E. Geier
    • 1
  • Daniel M. Newman
    • 2
  • Francis J. Fry
    • 3
  • Steven L. Griffith
    • 3
  • Thomas D. Franklin
    • 3
  1. 1.School of MedicineIndiana UniversityIndianapolisUSA
  2. 2.Methodist Hospital of IndianaInstitute for Kidney Stone DiseaseIndianapolisUSA
  3. 3.Indianapolis Center for Advanced ResearchIndianapolisUSA

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