Incidence of Nephropathy in Insulin-Dependent Diabetes as Related to Mortality

  • Knut Borch-Johnsen
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


Epidemiologic studies of patients with insulin-dependent diabetes mellitus (IDDM) have consistently shown that IDDM patients are characterized by a mortality rate that is 4–20 times higher than that of the general population [1, 2]. This excess mortality is predominantly ascribed to cardiovascular diseases and diabetic renal disease [3, 4]. However, the excess mortality has decreased by 30%–40% during the last 50 years [2]. Furthermore, it has been shown that development of persistent proteinuria (PP) is a marker of a very poor prognosis in IDDM patients [5–7]. Thus, two questions arise from these epidemiologic observations:
  1. 1.

    How does development of persistent proteinuria influence the mortality of IDDM patients?

  2. 2.

    Does the decreasing excess mortality of IDDM patients reflect a decreasing incidence of proteinuria?



Diabetic Nephropathy Diabetes Duration Relative Mortality IDDM Patient Persistent Proteinuria 
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© Springer Science+Business Media Dordrecht 1988

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  • Knut Borch-Johnsen

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