Part of the Topics in Renal Medicine book series (TIRM, volume 6)
Incidence of Nephropathy in Insulin-Dependent Diabetes as Related to Mortality
Epidemiologic studies of patients with insulin-dependent diabetes mellitus (IDDM) have consistently shown that IDDM patients are characterized by a mortality rate that is 4–20 times higher than that of the general population [1, 2]. This excess mortality is predominantly ascribed to cardiovascular diseases and diabetic renal disease [3, 4]. However, the excess mortality has decreased by 30%–40% during the last 50 years . Furthermore, it has been shown that development of persistent proteinuria (PP) is a marker of a very poor prognosis in IDDM patients [5–7]. Thus, two questions arise from these epidemiologic observations:
How does development of persistent proteinuria influence the mortality of IDDM patients?
Does the decreasing excess mortality of IDDM patients reflect a decreasing incidence of proteinuria?
KeywordsDiabetic Nephropathy Diabetes Duration Relative Mortality IDDM Patient Persistent Proteinuria
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media Dordrecht 1988