Skip to main content
SpringerLink
Log in

Recurrence of Diabetic Nephropathy in Renal Transplants

  • Chapter
The Kidney and Hypertension in Diabetes Mellitus

Part of the book series: Topics in Renal Medicine ((TIRM,volume 6))

Abstract

The first systematic studies of recurrent diabetic nephropathy in human renal transplants were carried out by the Minneapolis group [1, 2]. A light-microscopic study [1] showed that hyaline arteriolosclerosis had developed in all renal transplants of diabetic patients studied within 5 years after the transplantation. In several cases, it was shown that both the afferent and the efferent arterioles were affected, a condition considered more or less pathognomonic for diabetic nephropathy [3]. One of the biopsies also showed typical nodular glomerulosclerosis that had developed within 4 1/2 years after the transplantation [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mauer SM, Barbosa J, Vernier RL, Kjellstrand CM, Buselmeier TJ, Simmons RL, Najarian JS: Development of diabetic vascular lesions in normal kidneys transplanted into patients with diabetes mellitus. N Engl J Med 295: 916–920, 1976.

    Article  PubMed  CAS  Google Scholar 

  2. Mauer SM, Miller K, Goetz FC, Barbosa J, Simmons RL, Najarian JS, Michael AF: Immunopathology of renal extracellular membranes in kidneys transplanted into patients with diabetes mellitus. Diabetes 25: 709–712, 1976.

    Article  PubMed  CAS  Google Scholar 

  3. Heptinstall RH: Pathology of the kidney, vols 1 and 3, 3rd edn. Boston: Little, Brown and Company, 1983.

    Google Scholar 

  4. Westberg NG, Michael AF: Immunohistopathology of diabetic glomerulosclerosis. Diabetes 21: 163–174, 1972.

    PubMed  CAS  Google Scholar 

  5. Melvin T, Kim Y, Michael AF: Selective binding of IgG.r and other negatively charged plasma proteins in normal and diabetic human kidneys. Am J Pathol 115: 443–446, 1984.

    PubMed  CAS  Google Scholar 

  6. Lee CS, Mauer SM, Brown DM, Sutherland DER, Michael AF, Najarian JS: Renal transplantation in diabetes mellitus in rats. J Exp Med 139: 793–799, 1974.

    Article  PubMed  CAS  Google Scholar 

  7. Bohman S-O, Wilczek H, Jaremko G, Lundgren G: Recurrence of diabetic nephropathy in human renal allografts: preliminary report of a biopsy study. Transplant Proc 16: 649–653, 1984.

    PubMed  CAS  Google Scholar 

  8. Lundgren G, Wilczek H, Bohman S-O, Jaremko G, Groth CG: Development of diabetic nephropathy in renal allografts of diabetic patients. Transplant Proc 17: 18–20, 1985.

    Google Scholar 

  9. Bohman S-O, Jaremko G, Lundgren G, Tydén G, Wilczek H, Groth CG: Diabetic nephropathy in kidney transplants of diabetic patients, with a note on the protective effect of concomitant pancreatic transplantation. Diabetic Nephropathy 5: 55–57, 1985.

    Google Scholar 

  10. Frejkaer Thomsen O, Andersen AR, Sandahl Christiansen J, Deckert T: Renal changes in long-term type 1 (insulin-dependent) diabetic patients with and without clinical nephropathy: a light microscopic, morphometric study of autopsy material. Diabetologia 26: 361–365, 1984.

    Google Scholar 

  11. Deckert T, Parving H-H, Frokjaer Thomsen O, Jorgensen HE, Brun C, Thomsen AC: Renal structure and function in type 1 (insulin-dependent) diabetic patients: a study of 44 kidney biopsies. Diabetic Nephropathy 4: 163–168, 1985.

    Google Scholar 

  12. Andersen AR, Christiansen JS, Kreiner S, Deckert T: Diabetic nephropathy in type I (insulin-dependent) diabetes: an epidemiological study. Diabetologia 25: 496–501, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Mauer SM, Steffes MW, Ellis EE, Brown DM: Can the insulin-dependent diabetic patient be managed without kidney biopsy? In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 2. New York: Springer-Verlag, 1984, pp 1103–1108.

    Google Scholar 

  14. Barbosa J, Saner B: Do genetic factors play a role in the pathogenesis of diabetic nephropathy? Diabetologia 27: 487–492, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Richmond JD, Sturgill BC, Bolton WK: Recurrence of typical diffuse and nodular diabetic glomerulosclerosis in a renal allograft of a diabetic patient: functional deterioration in a six year old graft. Diabetic Nephropathy 3: 28–29, 1984.

    Google Scholar 

  16. Maryniak PK, Mendoza N, Clyne D, Balakrishnan K, Weiss MA: Recurrence of diabetic nodular glomerulosclerosis in a renal transplant. Transplantation 39: 35–38, 1985.

    Article  PubMed  CAS  Google Scholar 

  17. Wilczek H, Gunnarsson R, Lundgren G, Öst L: Improved results of renal transplantation in diabetic nephropathy. Transplant Proc 16: 623–627, 1984.

    PubMed  CAS  Google Scholar 

  18. Sutherland DER, Fryd DS, Strand M, Ascher N, Simmons RL, Najarian JS: Results of renal transplantation in diabetics at the University of Minnesota since 1979, including a comparison of outcome in diabetic and nondiabetic recipients randomized to cyclosporine versus azathioprine for immunosuppression. Transplant Proc 16: 629–632, 1984.

    PubMed  CAS  Google Scholar 

  19. Mogensen CE: Clinical and renal functional studies of diabetic nephropathy in humans. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 2. New York: Springer-Verlag, 1984, pp 1053–1073.

    Google Scholar 

  20. Hostetter TH, Rennke HG, Brenner BM: The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375–380, 1982.

    Article  PubMed  CAS  Google Scholar 

  21. Zatz R, Brenner BM: Pathogenesis of diabetic microangiopathy: the hemodynamic view. Am J Med 80: 443–453, 1985.

    Article  Google Scholar 

  22. Steffes MW, Brown DM, Mauer MM: Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes 27: 35–41, 1978.

    Article  PubMed  CAS  Google Scholar 

  23. Osterby R: Morphometric studies of the peripheral glomerular basement membrane in early juvenile diabetes. I. Development of initial basement membrane thickening. Diabetologia 8: 84–89, 1972.

    Article  PubMed  CAS  Google Scholar 

  24. fsterby R: A quantitative electron microscopic study of mesangial regions in glomeruli from patients with short term juvenile diabetes mellitus. Lab Invest 29: 99–110, 1973.

    Google Scholar 

  25. Mauer SM, Steffes MW, Ellis EE, Sutherland DER, Brown DM, Goetz FC: Structural—functional relationships in diabetic nephropathy. J Clin Invest 74: 1143–1155, 1984.

    Article  PubMed  CAS  Google Scholar 

  26. Mauer SM, Steffes MW, Connett J, Najarian JS, Sutherland DER, Barbosa J: The development of lesions in the glomerular basement membrane and mesangium after transplantation of normal kidneys to diabetic patients. Diabetes 32: 948–952, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Osterby R, Anderson AR, Gundersen HJ, Jorgensen HE, Mogensen CE, Parving H-H: Quantitative studies of glomerular ultrastructure in type I diabetics with incipient nephropathy. Diabetic Nephropathy 3: 95–100, 1984.

    Google Scholar 

  28. Steffes MW, Barbosa J, Basgen JM, Sutherland DER, Najarian JS, Mauer SM: Quantitative glomerular morphology of the normal human kidney. Lab Invest 49: 82–86, 1983.

    PubMed  CAS  Google Scholar 

  29. Steffes MW, Vernier RL, Brown DM, Basgen JM, Mauer SM: Diabetic glomerulopathy in the uninephrectomized rat resists amelioration following islet transplantation. Diabetologia 23: 347–353, 1982.

    Article  PubMed  CAS  Google Scholar 

  30. Sutherland DER, Moudry KC: Pancreas Transplant Registry report: 1986. Clin Transplant 1: 3–17, 1987.

    Google Scholar 

  31. Tydén G, Brattström C, Gunnarsson R, Lundgren G, Ost L, Östman J, Groth CG: Metabolic control 2 months to 4.5 years after pancreatic transplantation with special reference to the role of cyclosporin. Transplant Proc 19: 2294–2296, 1987.

    PubMed  Google Scholar 

  32. Orloff MJ, Yamanaka N, Greenleaf GE, Huang Y-T, Huang D-G, Leng X-S: Reversal of mesangial enlargement in rats with long-standing diabetes by whole pancreas transplantation. Diabetes 35: 347–354, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Steffes MW, Brown DM, Basgen JM, Matas AJ, Mauer SM: Glomerular basement membrane thickness following islet transplantation in the rat. Lab Invest 41: 116–118, 1979.

    PubMed  CAS  Google Scholar 

  34. Gotzsche O, Gundersen HJG, sterby R: Irreversibility of glomerular basement membrane accumulation despite reversibility of renal hypertrophy with islet transplantation in early experimental diabetes. Diabetes 30: 481–485, 1981.

    Article  PubMed  CAS  Google Scholar 

  35. Bohman S-O, Tydén G, Wilczek H, Lundgren G, Jaremko G, Gunnarsson R, Östman J, Groth CG: Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes 34: 306–308, 1985.

    Article  PubMed  CAS  Google Scholar 

  36. Bohman S-O, Wilczek H, Tydén G, Jaremko G, Lundgren G, Groth CG: Recurrent diabetic nephropathy in renal allografts placed in diabetic patients and protective effect of simultaneous pancreatic transplantation. Transplant Proc 19: 2290–2293, 1987.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Sven-Olof Bohman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Henryk Wilczek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Georg Jaremko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gunnar Tydén
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Aarhus Kommunehospital, Second University Clinic of Internal Medicine, DK-8000, Aarhus C, Denmark

    Carl Erik Mogensen MD

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Bohman, SO., Wilczek, H., Jaremko, G., Tydén, G. (1988). Recurrence of Diabetic Nephropathy in Renal Transplants. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_46

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1974-1_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1976-5

  • Online ISBN: 978-1-4757-1974-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation