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The Kidney and Hypertension in Diabetes Mellitus pp 117–130Cite as

Pathogenesis of Diabetic Glomerulopathy: A Biochemical View

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Part of the book series: Topics in Renal Medicine ((TIRM,volume 6))

Abstract

Half a century has now elapsed since Kimmelstiel and Wilson described in diabetic glomeruli the distinctive periodic acid—Schiff (PAS)-reactive nodular deposits that bear their names [1]. Since that time, these initial observations have been extended and it has become evident that, although the nodular lesions are frequently not present, the diabetic glomerular disease is always characterized by basement thickening and mesangial expansion [2, 3]. Indeed it is believed that progressive accumulation of glomerular extracellular matrix is an important aspect of the defect that leads to proteinuria and ultimately to capillary occlusion with the loss of functioning filtration units.

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Authors
  1. Robert G. Spiro
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Editors and Affiliations

  1. Aarhus Kommunehospital, Second University Clinic of Internal Medicine, DK-8000, Aarhus C, Denmark

    Carl Erik Mogensen MD

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Spiro, R.G. (1988). Pathogenesis of Diabetic Glomerulopathy: A Biochemical View. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_15

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  • DOI: https://doi.org/10.1007/978-1-4757-1974-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1976-5

  • Online ISBN: 978-1-4757-1974-1

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