Control of Lecithin Metabolism
The discovery of lecithin has been attributed to M. Gobley in 1847. Lecithin derives it’s name from the Greek word lekithos that means egg yolk. Remarkably, the stoichiometry of the chemical composition of lecithin was elucidated in the 1860’s by Diacknow and Strecker and the chemical synthesis of lecithin was achieved in 1927 by Grun and Limpacher. As has been the case for research in other areas of biology, once the chemistry of a natural product was elucidated, the stage was set for elucidating its biosynthesis. I usually attribute the biochemistry to have begun with the publication in 1932 by Best and Huntsman that choline in the diet would alleviate fatty livers that resulted from lecithin deficiency1. The next major development was Stetten and du Vigneaud’s demonstration in 1941 that it was possible to convert phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in rat liver.
KeywordsHydrocarbon Polycyclic Aromatic Hydrocarbon Cytosol Choline Oleate
Unable to display preview. Download preview PDF.
- 3.E.P. Kennedy, The Metabolism and Function of Complex Lipids, The Harvey Lectures 57:143–171 (1962).Google Scholar
- 7.W.J. Schneider and D.E. Vance, Conversion of Phosphatidylethanolamine to Phosphtidylcholine in Rat Liver, Partial Purification and Characterization of the Enzymatic Activities, J. Biol. Chem. 254: 3886–3891.Google Scholar
- 10.R. Sundler and B. Akesson, Regulation of Phospholipid Biosynthesis in Isolated Rat Hepatocytes, Effect of Different Substrates, J. Biol. Chem., 250: 3359–3367.Google Scholar
- 12.D.E. Vance and N. Ridgway, Methylation of Phosphatidylethanolamine: Enzyme Characterization, Regulation and Physiological Function in Biological Methylation and Drug Design. R.T. Borchardt, C.R. Creveling and P.M. Ueland eds., Humana Press, Clifton, New Jersey (1986).Google Scholar
- 15.K. Ishidate, K. Furusawa and Y. Nakazawa, Complete Co-Purification of Choline Kinase and Ethanolamine Kinase from Rat kidney and Immunological Evidence for Both Kinase Activities Residing on the Same Enzyme Protein(s) in Rat Tissues, Biochim Biophys. Acta 836:119–124 (1985).PubMedCrossRefGoogle Scholar
- 19.D.E. Vance and P.C. Choy, Trends Biochem. Science 4: 145–148 (1979).Google Scholar
- 23.R.B. Cornell, K. Ishidate, N.D. Ridgeway, J.S. Sanghera and D.E. Vance, The Enzymes of Phosphatidylcholine Biosynthesis in “Enzymes of Phospholipid Metabolism, S. Gatt, ed., In Press (1987).Google Scholar
- 28.P.H. Pritchari, P.K. Chiang, G.L. Cantoni and D.E. Vance, Inhibition of Phosphatidylethanolamine N-Methylation by 3-Deazaadenosine Stimulates the Synthesis of Phosphatidylcholine via the CDP-Choline Pathway, J. Biol. Chem. 257:6362–6367 (1982).Google Scholar
- 31.P.H. Lim, P.H. Pritchard, H.B. Paddon and D.E. Vance, Stimulation of Hepatic Phosphatidylcholine Biosynthesis in Rats fed a High Cholesterol and Cholate Diet Correlates with Translocation of CTP: Phosphocholine Cytidylyltransferase from Cytosol to Microsomes, Biochim Biophys. Acta 753:74–82 (1834).Google Scholar
- 35.R.B. Cornell and D.E. Vance, Translocation of CTP:Phosphocholine Cytidylyltransferase from Cytosol to Membranes in HeLa Cells: Stimulation by Fatty Acid, Fatty Alcohol, Mono-and Di-acylglycerol, Biochim. Biophys. Act, In Press (1987).Google Scholar
- 36.R.B. Cornell and D.E. Vance, Binding of CTP:Phosphocholine Cytidylyltransferase to Large Unilamellar Vesicles, Biochim. Biophys. Acta, In Press (1987).Google Scholar