Partial Synthesis of Glycerophospholipids
Glycerophospholipids obtained from natural sources, that is from plant, animal or microbial cells, are complex mixtures of phospholipid classes, subclasses and species. It is extremely difficult if not impossible to isolate, with available technology, individual phospholipid species from such mixtures. If one needs a chemically defined phospholipid, e.g., for biochemical or biophysical studies, for the preparation of lipid vesicles or liposomes, or as emulsifiers with well defined properties etc., then chemical synthesis is the only way to make these substances available. The use of synthetic methods is even more compulsory if the desired product is a radioactively or otherwise — spin, fluorescent or photoreactive — labeled phospholipid, or if it contains other “unnatural” rests, such as modified head groups or hydrophobic moieties.
KeywordsPhosphatidic Acid Phospholipid Class Acyl Migration Amino Alcohol Partial Synthesis
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