Dissemination and Activity of AL 721 after Oral Administration
Absorption of phospholipids in the small intestine is, in general, associated with hydrolysis by pancreatic lipases to water soluble products that eventualy reintegrate in the mucosa cells. An alternative route of phospholipid absorption is by endocytosis of small and tight assemblies like liposomes without hydrolysis. It might be therefore expected that shortly after absorption of phospholipids through one of these routes their composition in the blood stream is largely preserved. Along this rationale AL 721, a lipid mixture designated to reduce excess cholesterol from peripheral membranes, can be administered per os for in vivo application. A series of animal and human studies, where AL 721 was administered per os, lend support to this conclusion.
KeywordsHigh Density Lipoprotein Pancreatic Lipase Membrane Cholesterol Cell Plasma Membrane Mitogenic Stimulation
Unable to display preview. Download preview PDF.
- Cooper R.A., 1977, Abnormalities of cell membrane fluidity in the pathogenesis of disease, N. Eng. J. Med. 197:371.Google Scholar
- Cooper R.A. and Strauss J.F., 1984, Regulation of cell membrane cholesterol, in physiology of membrane fluidity (M. Shinitzky, ed) Vol. 1 pp. 73–98. CRC press, Boca Raton, Florida.Google Scholar
- Murata M., Imaizumi K. and Sugano M., 1982, Effect of dietary phospholipids and their constituent bases on serum lipids and apolipoproteins in rats J. Nutr. 112:1805.Google Scholar
- Parthasarathy S., Subbaigh P.V. and Ganguly J., 1974, The mechanism of intestinal absorption of phosphatidlylcholine in rats. Biochim. J. 140:503.Google Scholar
- Rabinowich H., Lyte M., Steiner A, Klajman A. and Shinitzky M., 1987, Partial restoration of immune competence in aged humans under a special lipid diet (AL 721). Mech. Age. Dev. in press.Google Scholar
- Rose H.G. and Oklander M., 1965, Analysis of erythrocyte membrane lipids J. Lipid Res. 6:428.Google Scholar
- Shenkin A. and Wretlind A., 1978, parenteral nutrition, Wed. Rev. Nutr. Diet. 28:1.Google Scholar
- Shinitzky M., Lyte M., Heron D. and Samuel D., 1983, Intervention in membrane aging — The development and application of Active Lipid, in Intervention in the aging process, part B. pp. 175-186. Alan R. Liss, Inc.Google Scholar
- Shinitzky M., 1984, Membrane fluidity and cellular functions, in Physiology of membrane fluidity (M. Shinitzky, ed) Vol. 1 pp. 1-51.Google Scholar