Cyclic Decapeptides in Kidney
The Cortinarius genus of mushrooms contains a number of species that have caused-poisonings throughout Europe. Cortinarins A and B have been isolated from these fungi and ascertained to be cyclic polypeptides; they have been shown in laboratory animals to cause nephro-toxicity characteristic of Cortinarius mushroom poisoning. HPLC systems, besides TLC, have been developed to examine methanolic extracts of kidney tissue from poisoned animals for these compounds, and for cortinarin C which is non-toxic. The toxicity of the mushrooms seems to entail a metabolic process, possibly explaining the genetic and sex-linked differences in susceptibility observed among individual humans and animals.
KeywordsMethanolic Extract Kidney Tissue Mouse Kidney Individual Human Kidney Toxicity
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