Determination of Phenothiazines: The Present-Day Scene

  • G. McKay
  • S. F. Cooper
  • K. K. Midha
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 16 A)

Abstract

Patients given antipsychotic drugs differ widely in the plasma concentrations, complicated by the presence of various metabolites, some active and some unstable. With phenothiazines, analytical difficulties besides low concentrations include adsorptive losses. Chemical methods, based on GC or HPLC with appropriate detectors, are specific and often sensitive but are laborious. RIA methods are sensitive and quick, but often non-specific such that we routinely validate them with specific chemical assays. This article considers the quantitative methods that we have developed for chlorpromazine, trifluoperazine, fluphenazine, trimethazine, proclorperazine and also their key metabolites.

Keywords

Monit Amitriptyline Chlorpromazine Tartrate Piperazine 

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • G. McKay
    • 1
  • S. F. Cooper
    • 1
    • 2
  • K. K. Midha
    • 1
  1. 1.College of PharmacyUniversity of SaskatchewanSaskatoonCanada
  2. 2.INRS-SantéUniversité du QuébecPointe-ClaireCanada

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