Nuclear Magnetic Resonance Studies of Intracellular pH and Myocardial Contractility during Ischemia
Most investigators in the field of molecular cardiology define myocardial ischemia in terms of a metabolic supply demand imbalance. Normal cell function is observed when supply is equal to or greater than demand. However, if coronary flow is reduced such that oxygen supply cannot meet the metabolic demands for the aerobic production of ATP (and phosphocreatine), then there must be a reduction in cell function1. In other words, cell function is in a delicate balance between metabolic (energetic) supply and its physiological demands, as illustrated by Equation 1.
KeywordsPerfusion Pressure Coronary Flow Coronary Blood Flow Myocardial Contractility Oxygen Utilization
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