Cardiology pp 569-582 | Cite as

Theoretical Implications of the use of Antioxidants for Heart Protection Against Stress-Induced and Ischemic Damages

  • F. Z. Meerson
  • V. E. Kagan


Ischemia, stress-induced catecholamine excess and, most commonly, a combination of these two factors are the key links in the pathogenesis of the coronary disease and other damages of the heart muscle. The experimental data obtained independently on models of acute is-schemia (Meerson, Kagan et al., 1982; Vasdev et al., 1979; Chien et al., 1979) and emotional-painful stress (Meerson, Kagan et al., 1980; Meerson, Arkhipenko et al., 1981) suggest that the crucial role in the damaging action of these factors, in particular in transition of reversible damages into irreversible ones, belongs to the events occurring at the level of the membrane lipid bilayer of cardio-myocytes. The excessive activation of at least three physiologically significant factors is of primary importance here, namely the activation of lipases and phospholipases, the activation of lipid peroxidation and the detergent-like action of lysophospholipids and free fatty acids (Katz and Messineo, 1981).


Lipid Peroxidation Heart Muscle Contractile Function Activate Oxygen Species Stress Damage 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • F. Z. Meerson
    • 1
    • 2
  • V. E. Kagan
    • 1
    • 2
  1. 1.Institute of General Pathology and Pathological PhysiologyMoscowUSSR
  2. 2.USSR Academy of Medical Sciences, School of BiologyMoscow State UniversityMoscowUSSR

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